(R)-2-{(4R,5S)-2,2-Dimethyl-5-[(R)-1-((S)-2-methyl-1-methylcarbamoyl-propylcarbamoyl)-3-phenyl-propyl]-[1,3]dioxolan-4-yl}-N-((S)-2-methyl-1-methylcarbamoyl-propyl)-4-phenyl-butyramide

Base Information

Chemical Name:(R)-2-{(4R,5S)-2,2-Dimethyl-5-[(R)-1-((S)-2-methyl-1-methylcarbamoyl-propylcarbamoyl)-3-phenyl-propyl]-[1,3]dioxolan-4-yl}-N-((S)-2-methyl-1-methylcarbamoyl-propyl)-4-phenyl-butyramide
CAS No.:372987-24-1
Molecular Formula:C₃₇H₅₄N₄O₆
Molecular Weight:650.859
Hs Code.:

(R)-2-{(4R,5S)-2,2-Dimethyl-5-[(R)-1-((S)-2-methyl-1-methylcarbamoyl-propylcarbamoyl)-3-phenyl-propyl]-[1,3]dioxolan-4-yl}-N-((S)-2-methyl-1-methylcarbamoyl-propyl)-4-phenyl-butyramide

Synonyms:(R)-2-{(4R,5S)-2,2-Dimethyl-5-[(R)-1-((S)-2-methyl-1-methylcarbamoyl-propylcarbamoyl)-3-phenyl-propyl]-[1,3]dioxolan-4-yl}-N-((S)-2-methyl-1-methylcarbamoyl-propyl)-4-phenyl-butyramide

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Chemical Property of (R)-2-{(4R,5S)-2,2-Dimethyl-5-[(R)-1-((S)-2-methyl-1-methylcarbamoyl-propylcarbamoyl)-3-phenyl-propyl]-[1,3]dioxolan-4-yl}-N-((S)-2-methyl-1-methylcarbamoyl-propyl)-4-phenyl-butyramide

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Technology Process of (R)-2-{(4R,5S)-2,2-Dimethyl-5-[(R)-1-((S)-2-methyl-1-methylcarbamoyl-propylcarbamoyl)-3-phenyl-propyl]-[1,3]dioxolan-4-yl}-N-((S)-2-methyl-1-methylcarbamoyl-propyl)-4-phenyl-butyramide

There total 5 articles about (R)-2-{(4R,5S)-2,2-Dimethyl-5-[(R)-1-((S)-2-methyl-1-methylcarbamoyl-propylcarbamoyl)-3-phenyl-propyl]-[1,3]dioxolan-4-yl}-N-((S)-2-methyl-1-methylcarbamoyl-propyl)-4-phenyl-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 372987-03-6
(3S,4R,5S,6S)-3,6-Bis-benzyloxymethyl-1,8-diphenyl-octane-4,5-diol

: 372987-24-1
(R)-2-{(4R,5S)-2,2-Dimethyl-5-[(R)-1-((S)-2-methyl-1-methylcarbamoyl-propylcarbamoyl)-3-phenyl-propyl]-[1,3]dioxolan-4-yl}-N-((S)-2-methyl-1-methylcarbamoyl-propyl)-4-phenyl-butyramide

Guidance literature:: Multi-step reaction with 5 steps

1: 2.29 g / (+/-)-camphor-10-sulfonic acid / acetone / 0.5 h

2: 1.27 g / H₂; NaHCO₃ / Pd/C / ethyl acetate; H₂O / 63 h / 20 °C

3: RuCl₃; NaIO₄ / acetonitrile; CH₂Cl₂; H₂O / 1.92 h

4: 393 mg / pyridine / acetonitrile

5: 1,2-dichloro-ethane / 22 h / 50 °C

With pyridine; ruthenium trichloride; sodium periodate; camphor-10-sulfonic acid; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; acetone; acetonitrile;
DOI:10.1021/jm0011171

Reference yield:

: 372987-07-0
(4S,5R)-4,5-Bis-((S)-1-benzyloxymethyl-3-phenyl-propyl)-2,2-dimethyl-[1,3]dioxolane

: 372987-24-1
(R)-2-{(4R,5S)-2,2-Dimethyl-5-[(R)-1-((S)-2-methyl-1-methylcarbamoyl-propylcarbamoyl)-3-phenyl-propyl]-[1,3]dioxolan-4-yl}-N-((S)-2-methyl-1-methylcarbamoyl-propyl)-4-phenyl-butyramide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.27 g / H₂; NaHCO₃ / Pd/C / ethyl acetate; H₂O / 63 h / 20 °C

2: RuCl₃; NaIO₄ / acetonitrile; CH₂Cl₂; H₂O / 1.92 h

3: 393 mg / pyridine / acetonitrile

4: 1,2-dichloro-ethane / 22 h / 50 °C

With pyridine; ruthenium trichloride; sodium periodate; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1021/jm0011171

Reference yield:

: 372987-10-5
(2S)-2-[(4R,5S)-5-[(1S)-1-(hydroxymethyl)-3-phenylpropyl]-2,2-dimethyl-1,3-dioxolan-4-yl]-4-phenyl-1-butanol

: 372987-24-1
(R)-2-{(4R,5S)-2,2-Dimethyl-5-[(R)-1-((S)-2-methyl-1-methylcarbamoyl-propylcarbamoyl)-3-phenyl-propyl]-[1,3]dioxolan-4-yl}-N-((S)-2-methyl-1-methylcarbamoyl-propyl)-4-phenyl-butyramide

Guidance literature:: Multi-step reaction with 3 steps

1: RuCl₃; NaIO₄ / acetonitrile; CH₂Cl₂; H₂O / 1.92 h

2: 393 mg / pyridine / acetonitrile

3: 1,2-dichloro-ethane / 22 h / 50 °C

With pyridine; ruthenium trichloride; sodium periodate; In dichloromethane; water; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1021/jm0011171