2',3'-O-isopropylidene-5'-methacryloyl-3-(4-methoxybenzyl)-5-fluorouridine

Base Information

• Chemical Name: 2',3'-O-isopropylidene-5'-methacryloyl-3-(4-methoxybenzyl)-5-fluorouridine
• CAS No.: 129141-71-5
• Molecular Formula: C₂₄H₂₇FN₂O₈
• Molecular Weight: 490.485
• Mol file: 129141-71-5.mol

Synonyms:2',3'-O-isopropylidene-5'-methacryloyl-3-(4-methoxybenzyl)-5-fluorouridine

Chemical Property of 2',3'-O-isopropylidene-5'-methacryloyl-3-(4-methoxybenzyl)-5-fluorouridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2',3'-O-isopropylidene-5'-methacryloyl-3-(4-methoxybenzyl)-5-fluorouridine

There total 4 articles about 2',3'-O-isopropylidene-5'-methacryloyl-3-(4-methoxybenzyl)-5-fluorouridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2',3'-O-Isopropylidene-3-(4-methoxybenzyl)-5-fluorouridine (129141-66-8) + Methacryloyl chloride (920-46-7,26937-45-1) → 2',3'-O-isopropylidene-5'-methacryloyl-3-(4-methoxybenzyl)-5-fluorouridine (129141-71-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile;

DOI:10.1246/cl.1990.339

Reference yield:

2',3'-O-isopropylidene-5-fluorouridine (2797-17-3) → 2',3'-O-isopropylidene-5'-methacryloyl-3-(4-methoxybenzyl)-5-fluorouridine (129141-71-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / N,N-diisopropylethylamine / acetonitrile / 3 h / Ambient temperature

2: N,N-diisopropylethylamine / acetonitrile / 4 h / Ambient temperature

With N-ethyl-N,N-diisopropylamine; In acetonitrile;

DOI:10.1246/bcsj.64.2266

Reference yield:

p-Methoxybenzyl bromide (2746-25-0) → 2',3'-O-isopropylidene-5'-methacryloyl-3-(4-methoxybenzyl)-5-fluorouridine (129141-71-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / N,N-diisopropylethylamine / acetonitrile / 3 h / Ambient temperature

2: N,N-diisopropylethylamine / acetonitrile / 4 h / Ambient temperature

With N-ethyl-N,N-diisopropylamine; In acetonitrile;

DOI:10.1246/bcsj.64.2266

upstream raw materials:

2',3'-O-Isopropylidene-3-(4-methoxybenzyl)-5-fluorouridine

Methacryloyl chloride

p-Methoxybenzyl bromide

p-methoxybenzyl chloride

Downstream raw materials:

5'-O-methacryloyl-3-(4-methoxybenzyl)-5-fluorouridine