cis 2-(2-bromoethyl)-5-<(methylsulphonyl)acetyl>-1-(p-tolylsulphonyl)pyrrolidine

Base Information

Chemical Name:cis 2-(2-bromoethyl)-5-<(methylsulphonyl)acetyl>-1-(p-tolylsulphonyl)pyrrolidine
CAS No.:111964-05-7
Molecular Formula:C₁₆H₂₂BrNO₅S₂
Molecular Weight:452.39
Hs Code.:

Synonyms:cis 2-(2-bromoethyl)-5-<(methylsulphonyl)acetyl>-1-(p-tolylsulphonyl)pyrrolidine

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Chemical Property of cis 2-(2-bromoethyl)-5-<(methylsulphonyl)acetyl>-1-(p-tolylsulphonyl)pyrrolidine

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Technology Process of cis 2-(2-bromoethyl)-5-<(methylsulphonyl)acetyl>-1-(p-tolylsulphonyl)pyrrolidine

There total 10 articles about cis 2-(2-bromoethyl)-5-<(methylsulphonyl)acetyl>-1-(p-tolylsulphonyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 133038-55-8
cis-2-(2-hydroxyethyl)-1-(p-tolylsulphonyl)-5-<(methylsulphonyl)acetyl>pyrrolidine

: 111964-05-7
cis 2-(2-bromoethyl)-5-<(methylsulphonyl)acetyl>-1-(p-tolylsulphonyl)pyrrolidine

Guidance literature:: With bromine; triphenylphosphine; In tetrahydrofuran; a) 0 deg C, 10 min, b) up to room temp.;

Reference yield:

: 112009-90-2
ethyl 2-benzylideneaminohepta-5,6-dienoate

: 111964-05-7
cis 2-(2-bromoethyl)-5-<(methylsulphonyl)acetyl>-1-(p-tolylsulphonyl)pyrrolidine

Guidance literature:: Multi-step reaction with 8 steps

1: 59 percent / aq. HCl / diethyl ether / 0.67 h / Ambient temperature

2: CH₂Cl₂

3: 88 percent / AgBF₄ / CH₂Cl₂ / 72 h / Ambient temperature

4: CF₃CO₂H / CH₂Cl₂ / Ambient temperature

5: pyridine / 0 °C

6: 1) B₂H₆, 2) aq. NaOH, 30percent aq. H₂O₂ / 1) THF, 20 deg C, 20 min, 2) 30 min, room temp.

7: 63 percent / tetrahydrofuran / 0.17 h / -10 °C

8: 78 percent / PPh₃, 2 M Br₂ / tetrahydrofuran / a) 0 deg C, 10 min, b) up to room temp.

With pyridine; hydrogenchloride; sodium hydroxide; dihydrogen peroxide; bromine; triphenylphosphine; trifluoroacetic acid; diborane; silver tetrafluoroborate; In tetrahydrofuran; diethyl ether; dichloromethane;

Reference yield:

: 133038-46-7
ethyl 2-(methoxycarbonylamino)hepta-5,6-dienoate

: 111964-05-7
cis 2-(2-bromoethyl)-5-<(methylsulphonyl)acetyl>-1-(p-tolylsulphonyl)pyrrolidine

Guidance literature:: Multi-step reaction with 6 steps

1: 83 percent / AgBF₄ / CH₂Cl₂ / 65 h / Ambient temperature

2: NaI, (CH₃)3SiCl / acetonitrile / 2 h / Heating

3: pyridine / 0 °C

4: 1) B₂H₆, 2) aq. NaOH, 30percent aq. H₂O₂ / 1) THF, 20 deg C, 20 min, 2) 30 min, room temp.

5: 63 percent / tetrahydrofuran / 0.17 h / -10 °C

6: 78 percent / PPh₃, 2 M Br₂ / tetrahydrofuran / a) 0 deg C, 10 min, b) up to room temp.

With pyridine; sodium hydroxide; chloro-trimethyl-silane; dihydrogen peroxide; bromine; triphenylphosphine; sodium iodide; diborane; silver tetrafluoroborate; In tetrahydrofuran; dichloromethane; acetonitrile;