O-(5'-dimethoxytrityl-2'-deoxythymidin-3'-yl)-O-(2',3'-dideoxythymidin-5'-yl) H-thiophosphonate

Base Information

Chemical Name:O-(5'-dimethoxytrityl-2'-deoxythymidin-3'-yl)-O-(2',3'-dideoxythymidin-5'-yl) H-thiophosphonate
CAS No.:650601-57-3
Molecular Formula:C₄₁H₄₃N₄O₁₁PS
Molecular Weight:830.852
Hs Code.:

Synonyms:O-(5'-dimethoxytrityl-2'-deoxythymidin-3'-yl)-O-(2',3'-dideoxythymidin-5'-yl) H-thiophosphonate

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Chemical Property of O-(5'-dimethoxytrityl-2'-deoxythymidin-3'-yl)-O-(2',3'-dideoxythymidin-5'-yl) H-thiophosphonate

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Technology Process of O-(5'-dimethoxytrityl-2'-deoxythymidin-3'-yl)-O-(2',3'-dideoxythymidin-5'-yl) H-thiophosphonate

There total 2 articles about O-(5'-dimethoxytrityl-2'-deoxythymidin-3'-yl)-O-(2',3'-dideoxythymidin-5'-yl) H-thiophosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.3%

: 126999-87-9,126999-89-1,225108-20-3
O-[5'-O-(4,4'-dimethoxytrityl)thymidine-3'-yl] H-thiophosphonate triethylamine salt

: 3056-17-5
stavudin

: 650601-57-3
O-(5'-dimethoxytrityl-2'-deoxythymidin-3'-yl)-O-(2',3'-dideoxythymidin-5'-yl) H-thiophosphonate

Guidance literature:: O-[5'-O-(4,4'-dimethoxytrityl)thymidine-3'-yl] H-thiophosphonate triethylamine salt; stavudin; With pyridine;

With pyridine; chlorophosphoric acid diphenyl ester; at 20 ℃; for 0.166667h;
DOI:10.1055/s-2003-41039

Reference yield:

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 650601-57-3
O-(5'-dimethoxytrityl-2'-deoxythymidin-3'-yl)-O-(2',3'-dideoxythymidin-5'-yl) H-thiophosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / 0.33 h / 20 °C

1.2: 84 percent / H₂S / dioxane / 0.33 h / 20 °C

2.1: pyridine

2.2: 69.3 percent / (C₆H₅O)2P(O)Cl; pyridine / 0.17 h / 20 °C

With pyridine;
DOI:10.1055/s-2003-41039