tert-butyl 5-(3-((4-((3-ethynyl-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

Base Information

Chemical Name:tert-butyl 5-(3-((4-((3-ethynyl-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate
CAS No.:1438085-62-1
Molecular Formula:C₃₁H₃₆FN₅O₄
Molecular Weight:561.656
Hs Code.:

Synonyms:tert-butyl 5-(3-((4-((3-ethynyl-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

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Chemical Property of tert-butyl 5-(3-((4-((3-ethynyl-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

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Technology Process of tert-butyl 5-(3-((4-((3-ethynyl-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

There total 11 articles about tert-butyl 5-(3-((4-((3-ethynyl-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.5%

: 141449-85-6
tert-butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

: 1437310-68-3
N-(3-ethynyl-4-fluorophenyl)-6-(3-chloropropoxy)-7-methoxyquinazolin-4-amine

: 1438085-62-1
tert-butyl 5-(3-((4-((3-ethynyl-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

Guidance literature:: With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 20 - 80 ℃; for 8h;

Reference yield:

: 230955-75-6
6-acetoxy-4-chloro-7-methoxyquinazoline

: 1438085-62-1
tert-butyl 5-(3-((4-((3-ethynyl-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: isopropyl alcohol / 83 °C

2: methanol; sodium hydroxide / 4 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 20 - 40 °C

4: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 8 h / 20 - 80 °C

With methanol; potassium carbonate; potassium iodide; sodium hydroxide; In N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 848591-86-6
5-benzyltetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione

: 1438085-62-1
tert-butyl 5-(3-((4-((3-ethynyl-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / -5 °C / Reflux

2: dichloromethane / 0 - 20 °C

3: hydrogen; palladium(II) hydroxide / methanol

4: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 8 h / 20 - 80 °C

With lithium aluminium tetrahydride; hydrogen; palladium(II) hydroxide; potassium carbonate; potassium iodide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;