1-(3,4,5-trimethoxyphenyl)-4-phenyl-1-azabuta-1,3-diene

Base Information

• Chemical Name: 1-(3,4,5-trimethoxyphenyl)-4-phenyl-1-azabuta-1,3-diene
• CAS No.: 100239-14-3
• Molecular Formula: C₁₈H₁₉NO₃
• Molecular Weight: 297.354
• Mol file: 100239-14-3.mol

Synonyms:1-(3,4,5-trimethoxyphenyl)-4-phenyl-1-azabuta-1,3-diene

Chemical Property of 1-(3,4,5-trimethoxyphenyl)-4-phenyl-1-azabuta-1,3-diene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3,4,5-trimethoxyphenyl)-4-phenyl-1-azabuta-1,3-diene

There total 1 articles about 1-(3,4,5-trimethoxyphenyl)-4-phenyl-1-azabuta-1,3-diene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

(E)-3-phenylpropenal (14371-10-9) + 3,4,5-Trimethoxyaniline (24313-88-0) → 1-(3,4,5-trimethoxyphenyl)-4-phenyl-1-azabuta-1,3-diene (100239-14-3)

Guidance literature:

With sodium sulfate; In diethyl ether; for 2h; Ambient temperature;

DOI:10.1002/(SICI)1099-0682(199807)1998:7<993::AID-EJIC993>3.0.CO;2-6

Reference yield: 63.0%

(2,3-Dioxo-2,3-dihydro-1H-indol-1-yl)acetic acid (60705-96-6) + 1-(3,4,5-trimethoxyphenyl)-4-phenyl-1-azabuta-1,3-diene (100239-14-3) → cis-(2-oxo-4-styryl-1-(3,4,5-trimethoxyphenyl)azetidin-3-yl)indoline-2,3-dione + trans-(2-oxo-4-styryl-1-(3,4,5-trimethoxyphenyl)azetidin-3-yl)indoline-2,3-dione

Guidance literature:

With triethylamine; p-toluenesulfonyl chloride; In dichloromethane; at 0 ℃; for 4h; diastereoselective reaction; Inert atmosphere;

DOI:10.1016/j.tetlet.2020.151602

Reference yield: 20.0%

ethyl 3-hydroxybutyrate (5405-41-4) + 1-(3,4,5-trimethoxyphenyl)-4-phenyl-1-azabuta-1,3-diene (100239-14-3) → 3-(1-Hydroxy-ethyl)-4-((E)-styryl)-1-(3,4,5-trimethoxy-phenyl)-azetidin-2-one (100239-21-2,100296-97-7,106399-75-1,106399-76-2,106399-77-3)

Guidance literature:

With lithium cyclohexylisopropylamide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; the reaction mixture was quenched at room temp.;

DOI:10.1016/S0040-4039(00)98683-0

upstream raw materials:

(E)-3-phenylpropenal

3,4,5-Trimethoxyaniline

Downstream raw materials:

3-(1-Hydroxy-ethyl)-4-((E)-styryl)-1-(3,4,5-trimethoxy-phenyl)-azetidin-2-one

Refernces