60705-96-6

Basic information

• Product Name: (2,3-DIOXO-2,3-DIHYDRO-INDOL-1-YL)-ACETIC ACID
• Synonyms: 2,3-dihydro-2,3-dioxo-1h-indole-1-aceticaci;2,3-dihydro-2,3-dioxo-1h-indole-1-aceticacid;2,3-dioxo-1-indolineaceticaci;2,3-dioxo-indoline-1-aceticaci;(2,3-DIOXO-2,3-DIHYDRO-1H-INDOL-1-YL)ACETIC ACID;(2,3-DIOXO-2,3-DIHYDRO-INDOL-1-YL)-ACETIC ACID;ISATIN-N-ACETIC ACID;CBI-BB ZERO/001450
• CAS NO: 60705-96-6
• Molecular Formula: C₁₀H₇NO₄
• Molecular Weight: 205.17
• Mol File: 60705-96-6.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 445.4 °C at 760 mmHg
• Flash Point: 223.2 °C
• Appearance: /
• Density: 1.522 g/cm³
• Vapor Pressure: 1.02E-08mmHg at 25°C
• Refractive Index: 1.639
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (2,3-DIOXO-2,3-DIHYDRO-INDOL-1-YL)-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (2,3-DIOXO-2,3-DIHYDRO-INDOL-1-YL)-ACETIC ACID(60705-96-6)
• EPA Substance Registry System: (2,3-DIOXO-2,3-DIHYDRO-INDOL-1-YL)-ACETIC ACID(60705-96-6)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25-36
• Safety Statements: 26-45
• HazardClass: IRRITANT
• Hazardous Substances Data: 60705-96-6(Hazardous Substances Data)

Usage

General Description

(2,3-Dioxo-2,3-dihydro-indol-1-yl)-acetic acid, also known as IDA, is a compound with a chemical structure containing a indolyl ring and a carboxylic acid group. It is a synthetic organic compound that has potential applications in the field of medicine and pharmaceuticals. It is a derivative of indole, which is a heterocyclic aromatic organic compound. IDA has been studied for its potential as an anti-inflammatory and analgesic agent, and it has also been investigated for its potential to inhibit leukemia cell growth. (2,3-DIOXO-2,3-DIHYDRO-INDOL-1-YL)-ACETIC ACID is of interest to researchers and scientists exploring the role of indole derivatives in developing new drugs and therapeutic agents.

InChI:InChI=1/C10H7NO4/c12-8(13)5-11-7-4-2-1-3-6(7)9(14)10(11)15/h1-4H,5H2,(H,12,13)

Upstream product

• 91-56-5 indole-2,3-dione 
• 105-36-2 ethyl bromoacetate 
• 107-59-5 tert-Butyl chloroacetate 
• 105-48-6 isopropyl chloroacetate 
• 265997-74-8 2-methyl-2-propanyl (2,3-dioxo-2,3-dihydro-1H-indol-1-yl)acetate 
• 41042-21-1 (1-ethoxycarbonylmethyl)isatin 
• 41042-20-0 methyl 2-(2,3-dioxoindolin-1-yl)acetate 
• 79-11-8 chloroacetic acid 

Relevant articles and documents

Isatin-1,2,4-oxadiazole compound as well as preparation method and application thereof

The invention discloses an isatin-1,2,4-diazole compound and a preparation method and application thereof. The structural general formula of the isatin-1,2,4-diazole compound is shown in the specification. According to the splicing principle of drugs and the structural drug molecular design concept, a five-membered heterocyclic structure is introduced to an isatin molecular skeleton of isatin, and the isatin-1,2,4-diazole derivative is obtained. A biological activity test result shows that the isatin-1,2,4-diazole compound disclosed by the invention has good inhibitory activity on mouse mononuclear macrophage leukemia cells.

Polyfunctional 4-quinolinones. Synthesis of 2-substituted 3-hydroxy-4-oxo-1,4-dihydroquinolines

We present here two new methods based on rearrangement reactions to obtain novel 2-substituted 3-hydroxy-4-oxo-1,4-dihydroquinolines, an important family of heterocycles with potential applications. Alkyl 3-hydroxy-4-oxo-1,4-dihydroquinoline-2-carboxylates were obtained by alkoxide promoted rearrangement of alkyl isatinacetates. A second synthetic route involves the alkoxide promoted reaction of both isatin and N-methylisatin, with alkylating agents having acidic methylenes. This reaction leads to the formation of spiroepoxyoxindoles via Darzens' condensation. When phenacyl bromides are used, the initially obtained benzoyl substituted spiroepoxyoxindoles were smoothly transformed into the corresponding 2-benzoyl-3-hydroxy-4-quinolinones with good to excellent yields.

Respiratory syncytial virus fusion inhibitors. Part 7: Structure-activity relationships associated with a series of isatin oximes that demonstrate antiviral activity in vivo

A series of bezimidazole-isatin oximes were prepared and profiled as inhibitors of respiratory syncytial virus (RSV) replication in cell culture. Structure-activity relationship studies were directed toward optimization of antiviral activity, cell permeab