(R)-N-(1-cyclohexylethyl)-N-methyl-2-oxo-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]acetamide

Base Information

Chemical Name:(R)-N-(1-cyclohexylethyl)-N-methyl-2-oxo-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]acetamide
CAS No.:615556-80-4
Molecular Formula:C₂₆H₃₀N₂O₄S
Molecular Weight:466.601
Hs Code.:

Synonyms:(R)-N-(1-cyclohexylethyl)-N-methyl-2-oxo-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]acetamide

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Chemical Property of (R)-N-(1-cyclohexylethyl)-N-methyl-2-oxo-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]acetamide

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Technology Process of (R)-N-(1-cyclohexylethyl)-N-methyl-2-oxo-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]acetamide

There total 4 articles about (R)-N-(1-cyclohexylethyl)-N-methyl-2-oxo-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 615556-79-1
(R)-N-(1-cyclohexylethyl)-2-oxo-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]acetamide

: 74-88-4
methyl iodide

: 615556-80-4
(R)-N-(1-cyclohexylethyl)-N-methyl-2-oxo-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]acetamide

Guidance literature:: With sodium hydride; at 0 ℃; for 2h;
DOI:10.1021/jo034719b

Reference yield:

: 120-72-9
indole

: 615556-80-4
(R)-N-(1-cyclohexylethyl)-N-methyl-2-oxo-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: diethyl ether / 0 °C

2: 1298 mg / diethyl ether / 20 °C

3: 90 percent / DMAP; i-Pr₂NEt / CH₂Cl₂ / 2 h / 20 °C

4: 34 percent / NaH / 2 h / 0 °C

With dmap; sodium hydride; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane;
DOI:10.1021/jo034719b

Reference yield:

: 22980-09-2
indolyl-3-glyoxylyl chloride

: 615556-80-4
(R)-N-(1-cyclohexylethyl)-N-methyl-2-oxo-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1298 mg / diethyl ether / 20 °C

2: 90 percent / DMAP; i-Pr₂NEt / CH₂Cl₂ / 2 h / 20 °C

3: 34 percent / NaH / 2 h / 0 °C

With dmap; sodium hydride; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane;
DOI:10.1021/jo034719b