6-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)methoxy)nicotinonitrile

Base Information

Chemical Name:6-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)methoxy)nicotinonitrile
CAS No.:1416733-66-8
Molecular Formula:C₂₂H₁₅F₄N₇O₂
Molecular Weight:485.4
Hs Code.:

Synonyms:6-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)methoxy)nicotinonitrile

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Chemical Property of 6-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)methoxy)nicotinonitrile

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Technology Process of 6-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)methoxy)nicotinonitrile

There total 6 articles about 6-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)methoxy)nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.2%

: 288-94-8
1H-tetrazole

: 1416733-67-9
6-((6-((2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)pyridin-3-yl)methoxy)nicotinonitrile

: 1416733-66-8
6-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)methoxy)nicotinonitrile

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 55 ℃; for 36h; Inert atmosphere;

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 1416733-66-8
6-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)methoxy)nicotinonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: copper / dimethyl sulfoxide / 1 h / 20 °C

1.2: 15 h / 20 °C

2.1: n-butyllithium / hexane; diethyl ether / -70 - 20 °C

3.1: diethyl ether / 0 - 20 °C

4.1: triethylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile / 16 h / 70 °C / 4137.29 Torr / Inert atmosphere

5.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 - 20 °C / Inert atmosphere

6.1: potassium carbonate / dimethyl sulfoxide; acetone / 20 - 55 °C / Inert atmosphere

7.1: potassium carbonate / N,N-dimethyl-formamide / 36 h / 55 °C / Inert atmosphere

With n-butyllithium; copper; diisobutylaluminium hydride; potassium carbonate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In diethyl ether; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;

Reference yield:

: 294181-95-6
2-(5-bromopyridine-2-yl)-2,2-difluoroacetic acid ethyl ester

: 1416733-66-8
6-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)methoxy)nicotinonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: n-butyllithium / hexane; diethyl ether / -70 - 20 °C

2: diethyl ether / 0 - 20 °C

3: triethylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile / 16 h / 70 °C / 4137.29 Torr / Inert atmosphere

4: diisobutylaluminium hydride / dichloromethane; toluene / -78 - 20 °C / Inert atmosphere

5: potassium carbonate / dimethyl sulfoxide; acetone / 20 - 55 °C / Inert atmosphere

6: potassium carbonate / N,N-dimethyl-formamide / 36 h / 55 °C / Inert atmosphere

With n-butyllithium; diisobutylaluminium hydride; potassium carbonate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In diethyl ether; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;