(3R)-3-ethyl-3-(2-hydroxyethyl)-1-[(1S)-2-hydroxy-1-phenylethyl]piperidine

Base Information

Chemical Name:(3R)-3-ethyl-3-(2-hydroxyethyl)-1-[(1S)-2-hydroxy-1-phenylethyl]piperidine
CAS No.:943739-66-0
Molecular Formula:C₁₇H₂₇NO₂
Molecular Weight:277.407
Hs Code.:

Synonyms:(3R)-3-ethyl-3-(2-hydroxyethyl)-1-[(1S)-2-hydroxy-1-phenylethyl]piperidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R)-3-ethyl-3-(2-hydroxyethyl)-1-[(1S)-2-hydroxy-1-phenylethyl]piperidine

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Technology Process of (3R)-3-ethyl-3-(2-hydroxyethyl)-1-[(1S)-2-hydroxy-1-phenylethyl]piperidine

There total 1 articles about (3R)-3-ethyl-3-(2-hydroxyethyl)-1-[(1S)-2-hydroxy-1-phenylethyl]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 943739-63-7
(3S,6R,8aR)-6-ethyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine-6-acetic acid

: 943739-66-0
(3R)-3-ethyl-3-(2-hydroxyethyl)-1-[(1S)-2-hydroxy-1-phenylethyl]piperidine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 28h;
DOI:10.1021/jo070397q

Reference yield:

: 943739-66-0
(3R)-3-ethyl-3-(2-hydroxyethyl)-1-[(1S)-2-hydroxy-1-phenylethyl]piperidine

: 4850-21-9
quebrachamine

Guidance literature:: Multi-step reaction with 7 steps

1: 69 percent / H₂ / Pd(OH)2/C / ethanol / 65 h / 20 °C / atmospheric pressure

2: pyridinium dichromate / dimethylformamide / 24 h / 20 °C

3: 70 mg / chlorotrimethylsilane / 24 h / 20 °C

4: 86 percent / tetrahydrofuran / 72 h / 20 °C

5: 74 percent / aqueous NaOH / methanol / 2.5 h / Heating

6: 85 percent / polyphosphoric acid / 0.5 h / 90 °C

7: 30 percent / LiAlH₄ / various solvent(s) / 7 h / Heating

With sodium hydroxide; lithium aluminium tetrahydride; dipyridinium dichromate; chloro-trimethyl-silane; PPA; hydrogen; palladium dihydroxide; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo070397q