tert-butyl 4-[3-formyl-1-(toluene-4-sulfonyl)-1H-indol-4-yl]piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-[3-formyl-1-(toluene-4-sulfonyl)-1H-indol-4-yl]piperazine-1-carboxylate
CAS No.:1258408-27-3
Molecular Formula:C₂₅H₂₉N₃O₅S
Molecular Weight:483.588
Hs Code.:

Synonyms:tert-butyl 4-[3-formyl-1-(toluene-4-sulfonyl)-1H-indol-4-yl]piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-[3-formyl-1-(toluene-4-sulfonyl)-1H-indol-4-yl]piperazine-1-carboxylate

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Technology Process of tert-butyl 4-[3-formyl-1-(toluene-4-sulfonyl)-1H-indol-4-yl]piperazine-1-carboxylate

There total 2 articles about tert-butyl 4-[3-formyl-1-(toluene-4-sulfonyl)-1H-indol-4-yl]piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1258408-25-1
tert-butyl 4-(3-formyl-1H-indol-4-yl)-piperazine-1-carboxylate

: 98-59-9
p-toluenesulfonyl chloride

: 1258408-27-3
tert-butyl 4-[3-formyl-1-(toluene-4-sulfonyl)-1H-indol-4-yl]piperazine-1-carboxylate

Guidance literature:: With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide; In water; toluene; at 20 ℃; for 0.75h;
DOI:10.1016/j.tet.2010.09.023

Reference yield:

: 252978-89-5
4-(1H-indol-4-yl)-piperazine-1-carboxylic acid tert-butyl ester

: 1258408-27-3
tert-butyl 4-[3-formyl-1-(toluene-4-sulfonyl)-1H-indol-4-yl]piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trichlorophosphate / 0.5 h / 20 °C / Inert atmosphere

1.2: 2.25 h / 0 °C

1.3: 0.5 h / 20 °C

2.1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / toluene; water / 0.75 h / 20 °C

With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide; trichlorophosphate; In water; toluene;

Reference yield: 51.0%

: 1258408-27-3
tert-butyl 4-[3-formyl-1-(toluene-4-sulfonyl)-1H-indol-4-yl]piperazine-1-carboxylate

: 1258408-29-5
tert-butyl 4-tosyl-6a,7,9,10-tetrahydro-4H-pyrazino[1,2-a]pyrrolo[4,3,2-de]quinoline-8(6H)-carboxylate

Guidance literature:: tert-butyl 4-[3-formyl-1-(toluene-4-sulfonyl)-1H-indol-4-yl]piperazine-1-carboxylate; With toluene-4-sulfonic acid hydrazide; In toluene; at 20 ℃; for 3h; Sonographic reaction;

With sodium hydride; In toluene; at 130 ℃; for 0.2h; Microwave irradiation; Inert atmosphere; Sealed tube;

With sodium hydrogencarbonate; In ethyl acetate; toluene;