252978-89-5

Basic information

• Product Name: 4-(1H-INDOL-4-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: 4-(1H-INDOL-4-YL)-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER;4-(1H-INDOL-4-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;4-(1H-INDOLE-4-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;CAY10492;1-Boc-4-(1H-indol-4-yl)piperazine;1-(1-tert-Butoxycarbonyl)-4-(4-indolyl)piperazine;tert-Butyl 4-(1H-indol-4-yl)piperazine-1-carboxylate;1-Piperazinecarboxylicacid,4-(1H-indol-4-yl)-,1,1-diMethylethylester
• CAS NO: 252978-89-5
• Molecular Formula: C₁₇H₂₃N₃O₂
• Molecular Weight: 301.38
• Mol File: 252978-89-5.mol
• Article Data: 9

Chemical Properties

• Melting Point: 139℃
• Boiling Point: 475.31 °C at 760 mmHg
• Flash Point: 241.259 °C
• Appearance: /
• Density: 1.194
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.607
• Storage Temp.: 2-8°C(protect from light)
• PKA: 18.78±0.30(Predicted)
• CAS DataBase Reference: 4-(1H-INDOL-4-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1H-INDOL-4-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(252978-89-5)
• EPA Substance Registry System: 4-(1H-INDOL-4-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(252978-89-5)

Safety Data

• Hazardous Substances Data: 252978-89-5(Hazardous Substances Data)

Usage

Description

CAY10492 is a synthetic intermediate useful for pharmaceutical synthesis..

InChI:InChI=1/C17H23N3O2/c1-17(2,3)22-16(21)20-11-9-19(10-12-20)15-6-4-5-14-13(15)7-8-18-14/h4-8,18H,9-12H2,1-3H3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 84807-09-0 4-(1-piperazinyl)-1H-indole 
• 255714-24-0 1-(1H-indol-4-yl)piperazine hydrochloride 
• 676448-13-8 4-(4-tert-butoxycarbonyl-piperazin-1-yl)-indole-1-carboxylic acid tert-butyl ester 
• 676448-17-2 4-bromoindole-1-carboxylic acid tert-butyl ester 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 431045-96-4 4-(5-chloro-1H-indol-4-yl)-piperazine-1-carboxylic acid tert-butyl ester 
• 431046-01-4 4-[1-(3-chloro-benzenesulfonyl)-1H-indol-4-yl]-piperazine-1-carboxylic acid tert-butyl ester 
• 393508-48-0 4-(1-benzenesulfonyl-1H-indol-4-yl)-piperazine-1-carboxylic acid tert-butyl ester 
• 412049-71-9 1-(phenylsulfonyl)-4-(1-piperazinyl)-1H-indole 
• 867348-22-9 4-(1-benzenesulfonyl-5-chloro-1H-indol-4-yl)-piperazine-1-carboxylic acid tert-butyl ester 
• 431045-97-5 4-[5-chloro-1-(3-chloro-benzenesulfonyl)-1H-indol-4-yl]-piperazine-1-carboxylic acid tert-butyl ester 
• 867348-24-1 4-[5-chloro-1-(4-chloro-benzenesulfonyl)-1H-indol-4-yl]-piperazine-1-carboxylic acid tert-butyl ester 
• 431046-34-3 4-[1-(3-chloro-benzenesulfonyl)-3-methyl-1H-indol-4-yl]-piperazine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

A dual-acting 5-HT6 receptor inverse agonist/MAO-B inhibitor displays glioprotective and pro-cognitive properties

The complex etiology of Alzheimer's disease has initiated a quest for multi-target ligands to address the multifactorial causes of this neurodegenerative disorder. In this context, we designed dual-acting 5-HT6 receptor (5-HT6R) anta

Deprotection of N-BOC compounds

Organic compounds having nitrogen atoms protected with t-butoxycarbonyl are effectively deprotected by heating in a fluorinated alcohol solution.

4' SUBSTITUTED COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein R1, R2, R5, R6, B, D, E, G, Q, x and n are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.