1H-Pyrrolo[1,2-c]imidazole-1,3(2H)-dione,tetrahydro-6-hydroxy-2-methyl-,(6R)-(9CI)

Base Information

Chemical Name:1H-Pyrrolo[1,2-c]imidazole-1,3(2H)-dione,tetrahydro-6-hydroxy-2-methyl-,(6R)-(9CI)
CAS No.:198084-55-8
Molecular Formula:C₇H₁₀N₂O₃
Molecular Weight:170.168
Hs Code.:
Mol file:198084-55-8.mol

Synonyms:1H-Pyrrolo[1,2-c]imidazole-1,3(2H)-dione,tetrahydro-6-hydroxy-2-methyl-,(6R)-(9CI)

Suppliers and Price of 1H-Pyrrolo[1,2-c]imidazole-1,3(2H)-dione,tetrahydro-6-hydroxy-2-methyl-,(6R)-(9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Pyrrolo[1,2-c]imidazole-1,3(2H)-dione,tetrahydro-6-hydroxy-2-methyl-,(6R)-(9CI)

Chemical Property:

Boiling Point:292.4±50.0 °C(Predicted)
PKA:13.85±0.20(Predicted)
PSA：60.85000
Density:1.50±0.1 g/cm3(Predicted)
LogP:-1.11060

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolo[1,2-c]imidazole-1,3(2H)-dione,tetrahydro-6-hydroxy-2-methyl-,(6R)-(9CI)

There total 1 articles about 1H-Pyrrolo[1,2-c]imidazole-1,3(2H)-dione,tetrahydro-6-hydroxy-2-methyl-,(6R)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 198084-54-7
7-hydroxy-1,3-diazabicyclo[3.3.0]octane-2,4-dione

: 74-88-4
methyl iodide

: 198084-55-8
7-hydroxy-3-methyl-1,3-diazabicyclo[3.3.0]octane-2,4-dione

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 65 ℃; for 3h;
DOI:10.1002/ardp.19973300808

Reference yield:

: 198084-55-8
7-hydroxy-3-methyl-1,3-diazabicyclo[3.3.0]octane-2,4-dione

: 198084-60-5
p-nitrobenzyl (1R,5S,6S)-6-((1R)-1-hydroxyethyl)-2-((5R,7S)-3-methyl-1,3-diazabicyclo[3.3.0]octane-2,4-dion-7-ylthio)-1-methylcarbapen-2-em-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

2: 79.1 percent / dimethylformamide; toluene / 3 h / 65 °C

3: 39.1 percent / 4 N NaOH / methanol / 0.17 h / 0 °C

4: 39 percent / iPr₂NEt / acetonitrile / 2 h / 0 °C

With sodium hydroxide; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1002/ardp.19973300808

Reference yield:

: 198084-55-8
7-hydroxy-3-methyl-1,3-diazabicyclo[3.3.0]octane-2,4-dione

: 198084-61-6
p-nitrobenzyl (1R,5S,6S)-6-((1R)-1-hydroxyethyl)-2-((5S,7S)-3-methyl-1,3-diazabicyclo[3.3.0]octane-2,4-dion-7-ylthio)-1-methylcarbapen-2-em-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

2: 79.1 percent / dimethylformamide; toluene / 3 h / 65 °C

3: 31 percent / 4 N NaOH / methanol / 0.17 h / 0 °C

4: 33 percent / iPr₂NEt / acetonitrile / 0 °C

With sodium hydroxide; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1002/ardp.19973300808