Technology Process of 2,5-bis(4-hydroxybenzyl)pyrazine
There total 7 articles about 2,5-bis(4-hydroxybenzyl)pyrazine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: ATP; NADPH; magnesium chloride; NRPS HqlA from Escherichia coli / aq. buffer / 37 °C / pH 7.7 / Enzymatic reaction
2: air
With
NRPS HqlA from Escherichia coli; ATP; NADPH; magnesium chloride;
In
aq. buffer;
DOI:10.1021/jacs.6b09464
- Guidance literature:
-
With
air;
In
methanol; dichloromethane;
at 20 ℃;
for 16h;
Inert atmosphere;
DOI:10.1039/c2ob06935k
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium tetrahydroborate; lithium chloride / tetrahydrofuran; ethanol / Inert atmosphere
2: sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide / 1 h / 0 - 20 °C / Inert atmosphere
3: 20% palladium hydroxide on charcoal; hydrogen; acetic acid / methanol; dichloromethane / 8 h / 30 °C
4: air / methanol; dichloromethane / 16 h / 20 °C / Inert atmosphere
With
sodium tetrahydroborate; 20% palladium hydroxide on charcoal; hydrogen; sulfur trioxide pyridine complex; acetic acid; N-ethyl-N,N-diisopropylamine; lithium chloride;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1039/c2ob06935k
