methyl 2-(4-(4-aminophenyl)thiazolidine-2-carboxamido)-3-methylbutanoate

Base Information

Chemical Name:methyl 2-(4-(4-aminophenyl)thiazolidine-2-carboxamido)-3-methylbutanoate
CAS No.:1210761-69-5
Molecular Formula:C₁₆H₁₉N₃O₃S
Molecular Weight:333.411
Hs Code.:

Synonyms:methyl 2-(4-(4-aminophenyl)thiazolidine-2-carboxamido)-3-methylbutanoate

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Chemical Property of methyl 2-(4-(4-aminophenyl)thiazolidine-2-carboxamido)-3-methylbutanoate

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Technology Process of methyl 2-(4-(4-aminophenyl)thiazolidine-2-carboxamido)-3-methylbutanoate

There total 5 articles about methyl 2-(4-(4-aminophenyl)thiazolidine-2-carboxamido)-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1287753-46-1
methyl 3-methyl-2-(2-(4-nitrophenyl)thiazole-4-carboxamido)butanoate

: 1210761-69-5
methyl 2-(4-(4-aminophenyl)thiazolidine-2-carboxamido)-3-methylbutanoate

Guidance literature:: With iron; ammonium chloride; In tetrahydrofuran; ethanol; water; for 2h; Reflux;

Reference yield:

: 619-80-7
4-nitrobenzamide

: 1210761-69-5
methyl 2-(4-(4-aminophenyl)thiazolidine-2-carboxamido)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 5 steps

1: Lawessons reagent / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

2: ethanol / 4 h / 80 °C / Inert atmosphere

3: lithium hydroxide; water / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 24 h / -20 - 20 °C / Inert atmosphere

5: ammonium chloride; iron / ethanol; tetrahydrofuran; water / 4 h / 80 °C / Inert atmosphere; Reflux

With Lawessons reagent; water; iron; ammonium chloride; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.05.006

Reference yield:

: 78979-64-3
ethyl 2-(4-nitrophenyl)thiazole-4-carboxylate

: 1210761-69-5
methyl 2-(4-(4-aminophenyl)thiazolidine-2-carboxamido)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide; water / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 24 h / -20 - 20 °C / Inert atmosphere

3: ammonium chloride; iron / ethanol; tetrahydrofuran; water / 4 h / 80 °C / Inert atmosphere; Reflux

With water; iron; ammonium chloride; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.05.006