619-80-7Relevant articles and documents
Wiberg
, p. 3961,3962 (1953)
Catalysis of the reaction between 4-nitrobenzoic acid and ammonia by boric acid + polyehylene glycol-400
Shteinberg
, p. 1715 - 1717 (2005)
Solvent effect on the synthesis of 4-nitrobenzamide by the reaction of 4-nitrobenzoic acid with ammonia in the presence of the catalytic system constituted by boric acid and polyethylene glycol-400 was studied.
New synthesis of 4-nintrobenzamide
Shteinberg
, p. 972 - 974 (2003)
The reaction of 4-nitrobenzoic acid with ammonia in the presence of various catalysts was studied. Tetrabutoxytitanium and boric acid with addition of PEG-400 favor formation of 4-nitrobenzamide in a high yield. The amidation occurs in the temperature range from 160 to 185°C in trichlorobenzene and in a mixture of trichlorobenzene with o-xylene. Neither PEG-400 nor the above catalysts in the absence of PEG-400 do not catalyze the reaction.
Ring Opening/Site Selective Cleavage in N-Acyl Glutarimide to Synthesize Primary Amides
Govindan, Karthick,Lin, Wei-Yu
supporting information, p. 1600 - 1605 (2021/03/03)
A LiOH-promoted hydrolysis selective C-N cleavage of twisted N-acyl glutarimide for the synthesis of primary amides under mild conditions has been developed. The reaction is triggered by a ring opening of glutarimide followed by C-N cleavage to afford primary amides using 2 equiv of LiOH as the base at room temperature. The efficacy of the reactions was considered and administrated for various aryl and alkyl substituents in good yield with high selectivity. Moreover, gram-scale synthesis of primary amides using a continuous flow method was achieved. It is noted that our new methodology can apply under both batch and flow conditions for synthetic and industrial applications.
Ruthenium(II) complexes bearing bidentate acylthiourea ligands for direct oxidation of amine α-carbon to amide
Aslan, Muhammed,Gumus, Ilkay
, (2021/10/07)
In this study, the synthesis and structural characterization of ruthenium complexes supported by S,O-acylthiourea ligands (L1-L6) with different substituent groups as well as auxiliary ligands PPH3, CO, and Cl and their evaluation as catalysts for direct oxidation of the α-methylene group in amines were reported. Ru(II) complexes, Ru1-Ru6, were prepared from the reaction of the RuH(CO)Cl(PPh3)3 precursor and ligands L1-L6 having different electronic and steric properties. The ligands and complexes prepared were characterized by FT-IR, 1H–13C- and/or 31P NMR spectroscopic techniques. The molecular structures of Ru1 and Ru3 complexes with appropriate crystal quality were also confirmed by X-ray single crystal analysis. Solid-state structures of Ru1 and Ru3 revealed that the ruthenium center is surrounded by one carbonyl, one chloride, two PPh3 ligands, and the S,O-donor atoms from the acylthiourea ligand in bidentate monoanionic form. The catalytic activity of all complexes for the α-oxygenation reactions of primary benzylic amines to amides was investigated. Overall, all catalysts exhibited excellent activity and selectivity towards the formation of amide production under the present reaction conditions. In addition, both catalyst activation and product selectivity/formation were particularly dependent on the amount/type of base and oxygen.
