Technology Process of methyl 2-(diphenylmethyleneamino)-3-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indol-3-yl)propanoate
There total 3 articles about methyl 2-(diphenylmethyleneamino)-3-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indol-3-yl)propanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
ethylaluminum dichloride;
In
hexane; dichloromethane;
at 0 - 20 ℃;
for 3h;
regioselective reaction;
Inert atmosphere;
DOI:10.1021/ol203216h
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tris-(dibenzylideneacetone)dipalladium(0); potassium acetate; XPhos / 1,4-dioxane / 20 h / 110 °C / Inert atmosphere
2: ethylaluminum dichloride / hexane; dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
With
tris-(dibenzylideneacetone)dipalladium(0); potassium acetate; ethylaluminum dichloride; XPhos;
In
1,4-dioxane; hexane; dichloromethane;
1: Miyaura borylation / 2: Friedel Crafts alkylation;
DOI:10.1021/ol203216h
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tris-(dibenzylideneacetone)dipalladium(0); potassium acetate; XPhos / 1,4-dioxane / 20 h / 110 °C / Inert atmosphere
2: ethylaluminum dichloride / hexane; dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
With
tris-(dibenzylideneacetone)dipalladium(0); potassium acetate; ethylaluminum dichloride; XPhos;
In
1,4-dioxane; hexane; dichloromethane;
1: Miyaura borylation / 2: Friedel Crafts alkylation;
DOI:10.1021/ol203216h
