3-[(2',6'-dimethylbiphenyl-3-yl)methoxy]bicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid

Base Information

Chemical Name:3-[(2',6'-dimethylbiphenyl-3-yl)methoxy]bicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid
CAS No.:1359668-71-5
Molecular Formula:C₂₄H₂₂O₃
Molecular Weight:358.437
Hs Code.:

Synonyms:3-[(2',6'-dimethylbiphenyl-3-yl)methoxy]bicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid

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Chemical Property of 3-[(2',6'-dimethylbiphenyl-3-yl)methoxy]bicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid

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Technology Process of 3-[(2',6'-dimethylbiphenyl-3-yl)methoxy]bicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid

There total 12 articles about 3-[(2',6'-dimethylbiphenyl-3-yl)methoxy]bicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1359669-49-0
3-[(2',6'-dimethylbiphenyl-3-yl)methoxy]bicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile

: 1359668-71-5
3-[(2',6'-dimethylbiphenyl-3-yl)methoxy]bicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid

Guidance literature:: 3-[(2',6'-dimethylbiphenyl-3-yl)methoxy]bicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile; With potassium hydroxide; In ethanol; water; at 20 ℃; for 69h; Reflux;

With hydrogenchloride; In ethanol; water;
DOI:10.1021/jm2012968

Reference yield:

: 691905-26-7
2',6'-dimethyl-[1,1'-biphenyl]-3-carbaldehyde

: 1359668-71-5
3-[(2',6'-dimethylbiphenyl-3-yl)methoxy]bicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / tetrahydrofuran; 1,2-dimethoxyethane / 0 °C

2: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / 20 °C

3: potassium hydroxide / ethanol; water / 69 h / 20 °C / Reflux

With sodium tetrahydroborate; tributylphosphine; potassium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; 2: Mitsunobu reaction;
DOI:10.1021/jm2012968

Reference yield:

: 100379-00-8
2,6-dimethylbenzene boronic acid

: 1359668-71-5
3-[(2',6'-dimethylbiphenyl-3-yl)methoxy]bicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene / Reflux

2: sodium tetrahydroborate / tetrahydrofuran; 1,2-dimethoxyethane / 0 °C

3: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / 20 °C

4: potassium hydroxide / ethanol; water / 69 h / 20 °C / Reflux

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tributylphosphine; sodium carbonate; potassium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; toluene; 1: Suzuki coupling / 3: Mitsunobu reaction;
DOI:10.1021/jm2012968