Technology Process of 1-[3-(phenylethynyl)benzoyl]-4-pyridin-2-ylpiperazine
There total 3 articles about 1-[3-(phenylethynyl)benzoyl]-4-pyridin-2-ylpiperazine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-(2-pyridyl)piperazine; 3-(2-phenylethynyl)benzoic acid;
In
N,N-dimethyl-formamide;
for 0.25h;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / 50 °C / Inert atmosphere
2.1: water; sodium hydroxide / methanol / 65 °C
2.2: pH 2 / Acidic conditions
3.1: N,N-dimethyl-formamide / 0.25 h
With
copper(l) iodide; water; triethylamine; sodium hydroxide;
bis-triphenylphosphine-palladium(II) chloride;
In
methanol; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: water; sodium hydroxide / methanol / 65 °C
1.2: pH 2 / Acidic conditions
2.1: N,N-dimethyl-formamide / 0.25 h
With
water; sodium hydroxide;
In
methanol; N,N-dimethyl-formamide;
