4-N-benzoyl-1-(2-O-benzoyloxymethoxymethyl-5-O-tert-butyldiphenylsilyl-β-D-ribofuranosyl)cytosine

Base Information

Chemical Name:4-N-benzoyl-1-(2-O-benzoyloxymethoxymethyl-5-O-tert-butyldiphenylsilyl-β-D-ribofuranosyl)cytosine
CAS No.:1332728-66-1
Molecular Formula:C₄₁H₄₃N₃O₉Si
Molecular Weight:749.893
Hs Code.:

Synonyms:4-N-benzoyl-1-(2-O-benzoyloxymethoxymethyl-5-O-tert-butyldiphenylsilyl-β-D-ribofuranosyl)cytosine

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Chemical Property of 4-N-benzoyl-1-(2-O-benzoyloxymethoxymethyl-5-O-tert-butyldiphenylsilyl-β-D-ribofuranosyl)cytosine

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Technology Process of 4-N-benzoyl-1-(2-O-benzoyloxymethoxymethyl-5-O-tert-butyldiphenylsilyl-β-D-ribofuranosyl)cytosine

There total 1 articles about 4-N-benzoyl-1-(2-O-benzoyloxymethoxymethyl-5-O-tert-butyldiphenylsilyl-β-D-ribofuranosyl)cytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: benzoyloxymethoxymethyl chloride

: 134821-65-1
4-N-benzoyl-1-(5-O-tert-butyldiphenylsilyl-β-D-ribofuranosyl)cytosine

: 1332728-66-1
4-N-benzoyl-1-(2-O-benzoyloxymethoxymethyl-5-O-tert-butyldiphenylsilyl-β-D-ribofuranosyl)cytosine

: 1332728-68-3
4-N-benzoyl-1-(3-O-benzoyloxymethoxymethyl-5-O-tert-butyldiphenylsilyl-β-D-ribofuranosyl)cytosine

Guidance literature:: 4-N-benzoyl-1-(5-O-tert-butyldiphenylsilyl-β-D-ribofuranosyl)cytosine; With dibutyltin chloride; N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 20 ℃; for 1h;

benzoyloxymethoxymethyl chloride; In 1,2-dichloro-ethane; at 85 ℃; for 3h;
DOI:10.1039/c1ob05488k

Reference yield:

: 1332728-66-1
4-N-benzoyl-1-(2-O-benzoyloxymethoxymethyl-5-O-tert-butyldiphenylsilyl-β-D-ribofuranosyl)cytosine

: 40615-36-9
4,4'-dimethoxytrityl chloride

: C₆₂H₆₁N₃O₁₁Si

Guidance literature:: With pyridine; silver trifluoromethanesulfonate; In pyridine; at 20 ℃; for 16h;
DOI:10.1039/c1ob05488k

Reference yield:

: 1332728-66-1
4-N-benzoyl-1-(2-O-benzoyloxymethoxymethyl-5-O-tert-butyldiphenylsilyl-β-D-ribofuranosyl)cytosine

: 1332728-84-3
4-N-benzoyl-1-(2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-β-D-ribofuranosyl)cytosine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; silver trifluoromethanesulfonate / pyridine / 16 h / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

With pyridine; tetrabutyl ammonium fluoride; silver trifluoromethanesulfonate; In tetrahydrofuran; pyridine;
DOI:10.1039/c1ob05488k