N,N-diisopropyl methyl [1-(4-N-benzoylcytosin-1-yl)-2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-β-D-ribofuranos-5-O-yl]phosphoramidite

Base Information

Chemical Name:N,N-diisopropyl methyl [1-(4-N-benzoylcytosin-1-yl)-2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-β-D-ribofuranos-5-O-yl]phosphoramidite
CAS No.:1332728-91-2
Molecular Formula:C₅₃H₅₉N₄O₁₂P
Molecular Weight:975.045
Hs Code.:

N,N-diisopropyl methyl [1-(4-N-benzoylcytosin-1-yl)-2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-β-D-ribofuranos-5-O-yl]phosphoramidite

Synonyms:N,N-diisopropyl methyl [1-(4-N-benzoylcytosin-1-yl)-2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-β-D-ribofuranos-5-O-yl]phosphoramidite

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Chemical Property of N,N-diisopropyl methyl [1-(4-N-benzoylcytosin-1-yl)-2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-β-D-ribofuranos-5-O-yl]phosphoramidite

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Technology Process of N,N-diisopropyl methyl [1-(4-N-benzoylcytosin-1-yl)-2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-β-D-ribofuranos-5-O-yl]phosphoramidite

There total 4 articles about N,N-diisopropyl methyl [1-(4-N-benzoylcytosin-1-yl)-2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-β-D-ribofuranos-5-O-yl]phosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1332728-84-3
4-N-benzoyl-1-(2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-β-D-ribofuranosyl)cytosine

: 92611-10-4
bis(N,N-diisopropylamino)methoxyphosphine

: 1332728-91-2
N,N-diisopropyl methyl [1-(4-N-benzoylcytosin-1-yl)-2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-β-D-ribofuranos-5-O-yl]phosphoramidite

Guidance literature:: With 1H-tetrazole; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1039/c1ob05488k

Reference yield:

: 1332728-66-1
4-N-benzoyl-1-(2-O-benzoyloxymethoxymethyl-5-O-tert-butyldiphenylsilyl-β-D-ribofuranosyl)cytosine

: 1332728-91-2
N,N-diisopropyl methyl [1-(4-N-benzoylcytosin-1-yl)-2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-β-D-ribofuranos-5-O-yl]phosphoramidite

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; silver trifluoromethanesulfonate / pyridine / 16 h / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

3: 1H-tetrazole / N,N-dimethyl-formamide / 2 h / 20 °C

With pyridine; 1H-tetrazole; tetrabutyl ammonium fluoride; silver trifluoromethanesulfonate; In tetrahydrofuran; pyridine; N,N-dimethyl-formamide;
DOI:10.1039/c1ob05488k

Reference yield:

: C₆₂H₆₁N₃O₁₁Si

: 1332728-91-2
N,N-diisopropyl methyl [1-(4-N-benzoylcytosin-1-yl)-2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-β-D-ribofuranos-5-O-yl]phosphoramidite

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

2: 1H-tetrazole / N,N-dimethyl-formamide / 2 h / 20 °C

With 1H-tetrazole; tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1039/c1ob05488k