(2R,3S)-3-benzyloxy-2-(N-methoxycarbonyl-N-benzylamino)-4-chlorobutyronitrile

Base Information

Chemical Name:(2R,3S)-3-benzyloxy-2-(N-methoxycarbonyl-N-benzylamino)-4-chlorobutyronitrile
CAS No.:276684-44-7
Molecular Formula:C₂₀H₂₁ClN₂O₃
Molecular Weight:372.851
Hs Code.:

Synonyms:(2R,3S)-3-benzyloxy-2-(N-methoxycarbonyl-N-benzylamino)-4-chlorobutyronitrile

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Chemical Property of (2R,3S)-3-benzyloxy-2-(N-methoxycarbonyl-N-benzylamino)-4-chlorobutyronitrile

Chemical Property:

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Technology Process of (2R,3S)-3-benzyloxy-2-(N-methoxycarbonyl-N-benzylamino)-4-chlorobutyronitrile

There total 6 articles about (2R,3S)-3-benzyloxy-2-(N-methoxycarbonyl-N-benzylamino)-4-chlorobutyronitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98944-53-7
(S)-2-O-benzyl-3-O-(tert-butyldimethylsilyl)-D-glyceraldehyde

: 276684-44-7
(2R,3S)-3-benzyloxy-2-(N-methoxycarbonyl-N-benzylamino)-4-chlorobutyronitrile

Guidance literature:: Multi-step reaction with 5 steps

1: MgSO₄ / tetrahydrofuran / 3 h

2: 64 percent / CH₂Cl₂ / 12 h / 20 °C

3: 98 percent / K₂CO₃ / tetrahydrofuran / 5 h / 20 °C

4: 99 percent / aq. AcOH / 96 h / 20 °C

5: 1.68 g / PPh₃; CCl₄ / 72 h / Heating

With tetrachloromethane; magnesium sulfate; potassium carbonate; acetic acid; triphenylphosphine; In tetrahydrofuran; dichloromethane; 1: Condensation / 2: Addition / 3: Acylation / 4: desilylation / 5: Chlorination;
DOI:10.1016/S0957-4166(00)00022-7

Reference yield:

: 100-46-9
benzylamine

: 276684-44-7
(2R,3S)-3-benzyloxy-2-(N-methoxycarbonyl-N-benzylamino)-4-chlorobutyronitrile

Guidance literature:: Multi-step reaction with 5 steps

1: MgSO₄ / tetrahydrofuran / 3 h

2: 64 percent / CH₂Cl₂ / 12 h / 20 °C

3: 98 percent / K₂CO₃ / tetrahydrofuran / 5 h / 20 °C

4: 99 percent / aq. AcOH / 96 h / 20 °C

5: 1.68 g / PPh₃; CCl₄ / 72 h / Heating

With tetrachloromethane; magnesium sulfate; potassium carbonate; acetic acid; triphenylphosphine; In tetrahydrofuran; dichloromethane; 1: Condensation / 2: Addition / 3: Acylation / 4: desilylation / 5: Chlorination;
DOI:10.1016/S0957-4166(00)00022-7

Reference yield:

: 276684-40-3
(S)-2-benzyloxy-3-(tert-butyldimethylsilyloxy)propylidene(benzyl)azane

: 276684-44-7
(2R,3S)-3-benzyloxy-2-(N-methoxycarbonyl-N-benzylamino)-4-chlorobutyronitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 64 percent / CH₂Cl₂ / 12 h / 20 °C

2: 98 percent / K₂CO₃ / tetrahydrofuran / 5 h / 20 °C

3: 99 percent / aq. AcOH / 96 h / 20 °C

4: 1.68 g / PPh₃; CCl₄ / 72 h / Heating

With tetrachloromethane; potassium carbonate; acetic acid; triphenylphosphine; In tetrahydrofuran; dichloromethane; 1: Addition / 2: Acylation / 3: desilylation / 4: Chlorination;
DOI:10.1016/S0957-4166(00)00022-7