2-(4-chlorophenyl)-9-cyano-5,6-dihydrothieno<2',3':2,3>thiepino<4,5-c>pyridazin-3(2H)-one

Base Information

Chemical Name:2-(4-chlorophenyl)-9-cyano-5,6-dihydrothieno<2',3':2,3>thiepino<4,5-c>pyridazin-3(2H)-one
CAS No.:173549-06-9
Molecular Formula:C₁₇H₁₀ClN₃OS₂
Molecular Weight:371.871
Hs Code.:

Synonyms:2-(4-chlorophenyl)-9-cyano-5,6-dihydrothieno<2',3':2,3>thiepino<4,5-c>pyridazin-3(2H)-one

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Chemical Property of 2-(4-chlorophenyl)-9-cyano-5,6-dihydrothieno<2',3':2,3>thiepino<4,5-c>pyridazin-3(2H)-one

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Technology Process of 2-(4-chlorophenyl)-9-cyano-5,6-dihydrothieno<2',3':2,3>thiepino<4,5-c>pyridazin-3(2H)-one

There total 8 articles about 2-(4-chlorophenyl)-9-cyano-5,6-dihydrothieno<2',3':2,3>thiepino<4,5-c>pyridazin-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 173549-09-2
2-(4-chlorophenyl)-9-formyl-5,6-dihydrothieno<2',3':2,3>thiepino<4,5-c>pyridazin-3(2H)-one

: 173549-06-9
2-(4-chlorophenyl)-9-cyano-5,6-dihydrothieno<2',3':2,3>thiepino<4,5-c>pyridazin-3(2H)-one

Guidance literature:: With hydroxylamine hydrochloride; sodium hydrogencarbonate; In ethanol; for 5h; Heating;
DOI:10.1016/0223-5234(96)88305-X

Reference yield:

: 135279-10-6
4-oxo-4,5,6,7-tetrahydrothieno<2,3-b>thiepin-5-acetonitrile

: 173549-06-9
2-(4-chlorophenyl)-9-cyano-5,6-dihydrothieno<2',3':2,3>thiepino<4,5-c>pyridazin-3(2H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: 78 percent / conc. HCl, acetic acid / 4 h / Heating

2: sodium acetate / ethanol / 15 h / Heating

3: sodium acetate / acetic acid / 3 h / Heating

4: 82 percent / HBr / dimethylsulfoxide; acetic acid / 0.5 h / Ambient temperature

5: 1.) phosphorus oxychloride / 1.) RT, 0.5 h, 2.) RT, 8 h

6: 60 percent / hydroxylamine hydrochloride, NaHCO₃ / ethanol / 5 h / Heating

With hydrogenchloride; hydroxylamine hydrochloride; hydrogen bromide; sodium acetate; sodium hydrogencarbonate; acetic acid; trichlorophosphate; In ethanol; acetic acid; dimethyl sulfoxide;
DOI:10.1016/0223-5234(96)88305-X

Reference yield:

: 135278-97-6
4-oxo-4,5,6,7-tetrahydrothieno<2,3-b>thiepin-5-acetic acid

: 173549-06-9
2-(4-chlorophenyl)-9-cyano-5,6-dihydrothieno<2',3':2,3>thiepino<4,5-c>pyridazin-3(2H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: sodium acetate / ethanol / 15 h / Heating

2: sodium acetate / acetic acid / 3 h / Heating

3: 82 percent / HBr / dimethylsulfoxide; acetic acid / 0.5 h / Ambient temperature

4: 1.) phosphorus oxychloride / 1.) RT, 0.5 h, 2.) RT, 8 h

5: 60 percent / hydroxylamine hydrochloride, NaHCO₃ / ethanol / 5 h / Heating

With hydroxylamine hydrochloride; hydrogen bromide; sodium acetate; sodium hydrogencarbonate; trichlorophosphate; In ethanol; acetic acid; dimethyl sulfoxide;
DOI:10.1016/0223-5234(96)88305-X