(S)-2-Acetyl-3-[1-phenyl-meth-(Z)-ylidene]-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione

Base Information

• Chemical Name: (S)-2-Acetyl-3-[1-phenyl-meth-(Z)-ylidene]-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione
• CAS No.: 126253-50-7
• Molecular Formula: C₁₆H₁₆N₂O₃
• Molecular Weight: 284.315

Synonyms:(S)-2-Acetyl-3-[1-phenyl-meth-(Z)-ylidene]-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione

Chemical Property of (S)-2-Acetyl-3-[1-phenyl-meth-(Z)-ylidene]-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione

Chemical Property:

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Technology Process of (S)-2-Acetyl-3-[1-phenyl-meth-(Z)-ylidene]-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione

There total 3 articles about (S)-2-Acetyl-3-[1-phenyl-meth-(Z)-ylidene]-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-proline (147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → (S)-2-Acetyl-3-[1-phenyl-meth-(Z)-ylidene]-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione (126253-50-7)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH / H₂O; acetone / 12 h / Ambient temperature

2: Ac₂O / 48 h / Ambient temperature

With sodium hydroxide; acetic anhydride; In water; acetone;

DOI:10.1016/S0040-4039(00)99413-9

Reference yield:

(Z)-4-benzylidene-2-methyl-5(4H)-oxazolone (38879-46-8) → (S)-2-Acetyl-3-[1-phenyl-meth-(Z)-ylidene]-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione (126253-50-7)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH / H₂O; acetone / 12 h / Ambient temperature

2: Ac₂O / 48 h / Ambient temperature

With sodium hydroxide; acetic anhydride; In water; acetone;

DOI:10.1016/S0040-4039(00)99413-9

Reference yield:

N-acetyl-α,β-dehydrophenylalanyl-(S)-proline (65941-28-8) → (S)-2-Acetyl-3-[1-phenyl-meth-(Z)-ylidene]-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione (126253-50-7)

Guidance literature:

With acetic anhydride; for 48h; Yield given; Ambient temperature;

DOI:10.1016/S0040-4039(00)99413-9

upstream raw materials:

N-acetyl-α,β-dehydrophenylalanyl-(S)-proline

L-proline

(Z)-4-benzylidene-2-methyl-5(4H)-oxazolone

Downstream raw materials:

6-acetyl-(7aS)-3a,6-diazaperhydroindane-4,7-dione-5-spiro-3'-<(3'S,4'S)-4'-phenyl-1'-pyrazoline>

C₁₆H₁₆N₂O₄

6-acetyl-(7aS)-3a,6-diazaperhydroindane-4,7-dione-5-spiro-1'-<(1'R,2'R)-2'-phenylcyclopropane>

(7aS)-3a,6-diazaperhydroindane-4,7-dione-5-spiro-1'-<(1'R,2'R)-2'-phenylcyclopropane>

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