(4Z)-2-Methyl-4-(phenylmethylidene)-4,5-dihydro-1,3-oxazol-5-one

Base Information

• Chemical Name: (4Z)-2-Methyl-4-(phenylmethylidene)-4,5-dihydro-1,3-oxazol-5-one
• CAS No.: 38879-46-8
• Molecular Formula: C11H9NO2
• Molecular Weight: 187.198
• Hs Code.: 2934999090
• Mol file: 38879-46-8.mol

Synonyms:2-Methyl-4-benzylidene-2-oxazolin-5-one;4-benzylidene-2-methyl-4H-oxazol-5-one;2-methyl-4-benzylidene-2-oxazoline-5-one;

Chemical Property of (4Z)-2-Methyl-4-(phenylmethylidene)-4,5-dihydro-1,3-oxazol-5-one

Chemical Property:

• PSA: 38.66000
• LogP: 1.43830

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4Z)-2-Methyl-4-(phenylmethylidene)-4,5-dihydro-1,3-oxazol-5-one

There total 15 articles about (4Z)-2-Methyl-4-(phenylmethylidene)-4,5-dihydro-1,3-oxazol-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

benzaldehyde (100-52-7) + N-acetylglycine (543-24-8) → (Z)-4-benzylidene-2-methyl-5(4H)-oxazolone (38879-46-8)

Guidance literature:

With sodium acetate; acetic anhydride; for 0.0666667h; microwave irradiation;

DOI:10.1016/j.tet.2005.09.104

Reference yield: 85.0%

1,3-diphenyl-1H-pyrazol-5-amine (5356-71-8) + benzaldehyde (100-52-7) + N-acetylglycine (543-24-8) → 4-benzylidene-2-methyl-1-(1,3-diphenyl-1H-pyrazol-5-yl)-1H-imidazol-5(4H)-one + (Z)-4-benzylidene-2-methyl-5(4H)-oxazolone (38879-46-8)

Guidance literature:

benzaldehyde; N-acetylglycine; With sodium acetate; acetic anhydride; Heating;

1,3-diphenyl-1H-pyrazol-5-amine; Heating;

DOI:10.3987/COM-10-11984

Reference yield: 80.0%

Hippuric Acid (495-69-2,140480-84-8,21251-67-2,91787-63-2,66407-11-2) + acetaldehyde (75-07-0,9002-91-9) → (Z)-4-benzylidene-2-methyl-5(4H)-oxazolone (38879-46-8)

Guidance literature:

With sodium acetate; acetic anhydride; at 100 - 110 ℃; for 4h;

DOI:10.1021/ol301741g

upstream raw materials:

2-(N-acetylamino)cinnamic acid

acetic anhydride

benzaldehyde

N-acetylglycine

Downstream raw materials:

4-benzylidene-2-methyl-4H-thiazol-5-one

N-acetyl dehydrophenylalanine cyclohexylamide

4-benzylidene-2-styryloxazolin-5-one

N-[1-(α-hydroxy-benzhydryl)-2-phenyl-vinyl]-acetamide