Technology Process of 1-formyl-1,2,3,4-tetrahydro-6,7-dimethoxy-4-phenylthioquinoline
There total 6 articles about 1-formyl-1,2,3,4-tetrahydro-6,7-dimethoxy-4-phenylthioquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
boron trifluoride diethyl etherate; trifluoroacetic anhydride;
In
benzene;
at 20 ℃;
for 1h;
DOI:10.1248/cpb.47.1269
- Guidance literature:
-
Multi-step reaction with 4 steps
1: NaI; Na2CO3; TEAB / dioxane / 144 h / Heating
2: Ac2O / 1 h / 60 °C
3: 96 percent / NaIO4 / methanol / 6 h / 20 °C
4: 84 percent / TFAA; BF3*Et2O / benzene / 1 h / 20 °C
With
sodium periodate; boron trifluoride diethyl etherate; tetraethylammonium bromide; acetic anhydride; sodium carbonate; trifluoroacetic anhydride; sodium iodide;
In
1,4-dioxane; methanol; benzene;
1: Condensation / 2: Formylation / 3: Oxidation / 4: Pummerer reaction;
DOI:10.1248/cpb.47.1269
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 83 percent / SOCl2 / pyridine / 10 h / 110 °C
2: NaI; Na2CO3; TEAB / dioxane / 144 h / Heating
3: Ac2O / 1 h / 60 °C
4: 96 percent / NaIO4 / methanol / 6 h / 20 °C
5: 84 percent / TFAA; BF3*Et2O / benzene / 1 h / 20 °C
With
sodium periodate; thionyl chloride; boron trifluoride diethyl etherate; tetraethylammonium bromide; acetic anhydride; sodium carbonate; trifluoroacetic anhydride; sodium iodide;
In
1,4-dioxane; pyridine; methanol; benzene;
1: Chlorination / 2: Condensation / 3: Formylation / 4: Oxidation / 5: Pummerer reaction;
DOI:10.1248/cpb.47.1269
