6,7-dimethoxy-1,2,3,4-tetrahydroquinoline

Base Information

• Chemical Name: 6,7-dimethoxy-1,2,3,4-tetrahydroquinoline
• CAS No.: 99986-04-6
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.246
• Hs Code.: 2933499090
• Mol file: 99986-04-6.mol

Synonyms:1,2,3,4-Tetrahydro-6,7-dimethoxyquinoline

Chemical Property of 6,7-dimethoxy-1,2,3,4-tetrahydroquinoline

Chemical Property:

• PSA: 30.49000
• LogP: 2.19990

Purity/Quality:

98%Min ^*data from raw suppliers

6,7-Dimethoxy-1,2,3,4-tetrahydroquinoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6,7-dimethoxy-1,2,3,4-tetrahydroquinoline

There total 11 articles about 6,7-dimethoxy-1,2,3,4-tetrahydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-formyl-1,2,3,4-tetrahydro-6,7-dimethoxyquinoline (250156-36-6) → 1,2,3,4-tetrahydro-6,7-dimethoxyquinoline (99986-04-6)

Guidance literature:

With sodium hydroxide; In ethanol; for 6h; Heating;

DOI:10.1248/cpb.47.1269

Reference yield: 68.0%

6,7-dimethoxy-3,4-dihydroquinolin-2(1H)-one (91133-47-0) → 1,2,3,4-tetrahydro-6,7-dimethoxyquinoline (99986-04-6)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1016/j.bmc.2011.02.006

Reference yield:

6,7-Dimethoxy-chinolin (67278-27-7) → 1,2,3,4-tetrahydro-6,7-dimethoxyquinoline (99986-04-6)

Guidance literature:

With ethanol; sodium;

DOI:10.1039/jr9510001150

upstream raw materials:

6,7-Dimethoxy-chinolin

6,7-dimethoxy-3,4-dihydroquinolin-2(1H)-one

6,7-dimethoxy-3,4-dihydro-1H-quinoline-2-thione

1-formyl-1,2,3,4-tetrahydro-6,7-dimethoxyquinoline

Downstream raw materials:

5-bromo-N-(4-(6,7-dimethoxy-3,4-dihydroquinolin-1(2H)-yl)butyl)-2,3-dimethoxybenzamide

6,7-Dimethoxy-chinolin

1-(N-acetyl-sulfanilyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-quinoline

Refernces

• 1、 Toda, Jun,Sakagami, Michiya,Sano, Takehiro. "A novel synthesis of 1,2,3,4-tetrahydroquinolines via Pummerer-type reaction of N-aryl-N-[(phenylsulfinyl)propyl]formamide". . p. 1269 - 1275. Retrieved 2007/10/03.