(S)-4-Phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pentan-2-one

Base Information

Chemical Name:(S)-4-Phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pentan-2-one
CAS No.:1239568-87-6
Molecular Formula:C₁₇H₂₅BO₃
Molecular Weight:288.195
Hs Code.:

Synonyms:(S)-4-Phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pentan-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-4-Phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pentan-2-one

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Technology Process of (S)-4-Phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pentan-2-one

There total 4 articles about (S)-4-Phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pentan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 827-69-0
(E)-4-phenyl-3-penten-2-one

: 73183-34-3
bis(pinacol)diborane

: 1239568-87-6
(S)-4-Phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pentan-2-one

Guidance literature:: With tetrakis(actonitrile)copper(I) hexafluorophosphate; (1S,2S)-N,N'-diethyl-1,2-diphenyl-1,2-ethanediamine; isopropyl alcohol; lithium tert-butoxide; In tetrahydrofuran; 1,2-dimethoxyethane; at 20 ℃; for 24.1667h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ol101691p

Reference yield: 58.0%

: 51384-73-7,55543-90-3,827-69-0
4-phenyl-3-penten-2-one

: 73183-34-3
bis(pinacol)diborane

: 1239568-87-6
(S)-4-Phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pentan-2-one

Guidance literature:: With BF₄^(1-)*C₃₉H₃₉N₂⁽¹⁺⁾; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; methanol; at 22 ℃; for 14h; enantioselective reaction; Glovebox; Inert atmosphere;
DOI:10.1002/anie.201309982

Reference yield:

: 827-69-0
(E)-4-phenyl-3-penten-2-one

: 73183-34-3
bis(pinacol)diborane

: 1239568-87-6
(S)-4-Phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pentan-2-one

: (R)-4-Phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pentan-2-one

Guidance literature:: With (R,R)-(?)-2,3-bis(t-butylmethylphosphino)quinoxaline; tetrakis(actonitrile)copper(I) hexafluorophosphate; lithium tert-butoxide; In dimethyl sulfoxide; at 20 ℃; for 24h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ol101691p