ethyl 2-[4-[[(2E)-2-hydroxyiminoacetyl]amino]phenyl]-2-methylpropanoate

Base Information

• Chemical Name: ethyl 2-[4-[[(2E)-2-hydroxyiminoacetyl]amino]phenyl]-2-methylpropanoate
• CAS No.: 1309089-22-2
• Molecular Formula: C₁₄H₁₈N₂O₄
• Molecular Weight: 278.308
• Mol file: 1309089-22-2.mol

Synonyms:ethyl 2-[4-[[(2E)-2-hydroxyiminoacetyl]amino]phenyl]-2-methylpropanoate

Chemical Property of ethyl 2-[4-[[(2E)-2-hydroxyiminoacetyl]amino]phenyl]-2-methylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-[4-[[(2E)-2-hydroxyiminoacetyl]amino]phenyl]-2-methylpropanoate

There total 1 articles about ethyl 2-[4-[[(2E)-2-hydroxyiminoacetyl]amino]phenyl]-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

chloral hydrate (302-17-0) + 2-(4-amino-phenyl)-2-methyl-propionic acid ethyl ester; hydrochloride → ethyl 2-[4-[[(2E)-2-hydroxyiminoacetyl]amino]phenyl]-2-methylpropanoate (1309089-22-2)

Guidance literature:

chloral hydrate; With sodium sulfate; In water; at 23 ℃; for 0.166667h;

2-(4-amino-phenyl)-2-methyl-propionic acid ethyl ester; hydrochloride; With hydroxylamine hydrochloride; In water; at 60 ℃; for 5h;

Reference yield:

ethyl 2-[4-[[(2E)-2-hydroxyiminoacetyl]amino]phenyl]-2-methylpropanoate (1309089-22-2) → ethyl 2-[4-(tert-butoxycarbonylamino)-3-(2-isoindolin-2-yl-2-oxoacetyl)phenyl]-2-methylpropanoate (1309089-25-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / 2 h / 50 - 60 °C

2: dmap / tetrahydrofuran / 12 h / 23 °C

3: tetrahydrofuran / 1 h / 23 °C

With dmap; sulfuric acid; In tetrahydrofuran;

upstream raw materials:

chloral hydrate

Downstream raw materials:

ethyl 2-[4-(tert-butoxycarbonylamino)-3-(2-isoindolin-2-yl-2-oxoacetyl)phenyl]-2-methylpropanoate