N-cyclohexyl-N-methyl-2-carboxy-4<(1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide

Base Information

Chemical Name:N-cyclohexyl-N-methyl-2-carboxy-4<(1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide
CAS No.:116005-63-1
Molecular Formula:C₂₂H₂₈N₄O₅
Molecular Weight:428.488
Hs Code.:

Synonyms:N-cyclohexyl-N-methyl-2-carboxy-4<(1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide

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Chemical Property of N-cyclohexyl-N-methyl-2-carboxy-4<(1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide

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Technology Process of N-cyclohexyl-N-methyl-2-carboxy-4<(1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide

There total 6 articles about N-cyclohexyl-N-methyl-2-carboxy-4<(1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 116005-62-0
N-cyclohexyl-N-methyl-2-(ethoxycarbonyl)-4<(1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide

: 116005-63-1
N-cyclohexyl-N-methyl-2-carboxy-4<(1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide

Guidance literature:: With potassium hydroxide; In ethanol; for 1h; Ambient temperature;
DOI:10.1021/jm00119a015

Reference yield:

: 100-60-7
N-methylcyclohexylamine

: 116005-63-1
N-cyclohexyl-N-methyl-2-carboxy-4<(1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide

Guidance literature:: Multi-step reaction with 4 steps

1: 49 percent / Et₃N / tetrahydrofuran / 0.5 h / Ambient temperature

2: 62 percent / 1.) NaH, 2.) tetra-n-butylammonium iodide / tetrahydrofuran / 1.) room temperature, 1 h, 2.) reflux, 5 days

4: 86 percent / aq. KOH / ethanol / 1 h / Ambient temperature

With potassium hydroxide; tetra-(n-butyl)ammonium iodide; sodium hydride; triethylamine; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00119a015

Reference yield:

: 116005-59-5
5-(2-chloroethoxy)-2-nitrobenzaldehyde

: 116005-63-1
N-cyclohexyl-N-methyl-2-carboxy-4<(1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / acetic acid / methanol / Ambient temperature

2: 62 percent / 1.) NaH, 2.) tetra-n-butylammonium iodide / tetrahydrofuran / 1.) room temperature, 1 h, 2.) reflux, 5 days

4: 86 percent / aq. KOH / ethanol / 1 h / Ambient temperature

With potassium hydroxide; tetra-(n-butyl)ammonium iodide; sodium hydride; acetic acid; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jm00119a015