2-[(4-fluorobenzenesulfonyl)-(2-hydroxyethyl)amino]-N-[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]acetamide

Base Information

Chemical Name:2-[(4-fluorobenzenesulfonyl)-(2-hydroxyethyl)amino]-N-[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]acetamide
CAS No.:1590397-12-8
Molecular Formula:C₂₂H₂₀F₄N₄O₄S
Molecular Weight:512.485
Hs Code.:

Synonyms:2-[(4-fluorobenzenesulfonyl)-(2-hydroxyethyl)amino]-N-[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]acetamide

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Chemical Property of 2-[(4-fluorobenzenesulfonyl)-(2-hydroxyethyl)amino]-N-[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]acetamide

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Technology Process of 2-[(4-fluorobenzenesulfonyl)-(2-hydroxyethyl)amino]-N-[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]acetamide

There total 5 articles about 2-[(4-fluorobenzenesulfonyl)-(2-hydroxyethyl)amino]-N-[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1590397-77-5
[(4-fluorobenzenesulfonyl)-(2-hydroxyethyl)amino]acetic acid

: 1257437-46-9
[6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]methylamine

: 1590397-12-8
2-[(4-fluorobenzenesulfonyl)-(2-hydroxyethyl)amino]-N-[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]acetamide

Guidance literature:: With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 2h;

Reference yield:

: 1590397-76-4
[(4-fluorobenzenesulfonyl)-(2-hydroxyethyl)amino]acetic acid ethyl ester

: 1590397-12-8
2-[(4-fluorobenzenesulfonyl)-(2-hydroxyethyl)amino]-N-[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide; water / 1,4-dioxane / 1 h

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h

With water; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1590397-12-8
2-[(4-fluorobenzenesulfonyl)-(2-hydroxyethyl)amino]-N-[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; water; ethanol / 7 h / 130 °C

2: 1,4-diaza-bicyclo[2.2.2]octane / acetonitrile / 2 h / 0 °C

3: palladium 10% on activated carbon; hydrogen / 3 h / 2585.81 Torr

4: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h

With 1,4-diaza-bicyclo[2.2.2]octane; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; hydrogen; sodium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; acetonitrile; 1: |Suzuki Coupling;