1590397-76-4

Upstream product

• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 214709-53-2 (2-hydroxy-ethylamino)-acetic acid ethyl ester 

Downstream Products

• 1590397-01-5 2-[(4-fluorobenzenesulfonyl)-(2-hydroxyethyl)amino]-N-(4'-trifluoromethylbiphenyl-3-ylmethyl)acetamide 
• 1590397-77-5 [(4-fluorobenzenesulfonyl)-(2-hydroxyethyl)amino]acetic acid 
• 1590397-12-8 2-[(4-fluorobenzenesulfonyl)-(2-hydroxyethyl)amino]-N-[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]acetamide 

Relevant academic research and scientific papers

Combination of click chemistry and sulfonamides to develop three-armed triazole compounds

Fragment-based drug discovery is a valuable tool in hit identification, as well as the combination of different small fragments showing a minimal binding activity against biological receptors or enzymes to give merged hits. A high number of fragments on the same scaffold improve the probability to find a candidate showing single- or multi-target affinities. A rapid and versatile approach for synthesizing libraries of densely fragment-functionalized scaffolds is reported. Many fragments were assembled in few steps around a triazole ring starting from amino alcohols and other readily available building blocks. A binding assay against integrin αvβ3 was used as a test-bed in order to demonstrate the potential of such an approach in hit discovery strategies.

SUBSTITUTED SULFONAMIDE COMPOUNDS

The invention is concerned with the compounds of formula (I), and salts thereof, wherein X, Y, Z, R1, R2, R3, R3, R4, R5 and R6 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of Formula (I) as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.