tert-butyl 2-(4-cyano-3,5-difluorophenyl)hydrazinecarboxylate

Base Information

• Chemical Name: tert-butyl 2-(4-cyano-3,5-difluorophenyl)hydrazinecarboxylate
• CAS No.: 1073973-04-2
• Molecular Formula: C₁₂H₁₃F₂N₃O₂
• Molecular Weight: 269.251
• Mol file: 1073973-04-2.mol

Synonyms:tert-butyl 2-(4-cyano-3,5-difluorophenyl)hydrazinecarboxylate

Chemical Property of tert-butyl 2-(4-cyano-3,5-difluorophenyl)hydrazinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of tert-butyl 2-(4-cyano-3,5-difluorophenyl)hydrazinecarboxylate

There total 1 articles about tert-butyl 2-(4-cyano-3,5-difluorophenyl)hydrazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

t-butoxycarbonylhydrazine (870-46-2) + 2,4,6-trifluorobenzonitrile (96606-37-0,103498-69-7) → tert-butyl 2-(4-cyano-3,5-difluorophenyl)hydrazinecarboxylate (1073973-04-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 20 ℃; for 120.16h;

Reference yield: 67.0%

tert-butyl 2-(4-cyano-3,5-difluorophenyl)hydrazinecarboxylate (1073973-04-2) + 2-acetyldimedone (1755-15-3) → (2,6-difluoro-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzonitrile) (1073973-05-3)

Guidance literature:

tert-butyl 2-(4-cyano-3,5-difluorophenyl)hydrazinecarboxylate; 2-acetyldimedone; With acetic acid; In ethanol; at 110 ℃; for 8h;

With sodium hydrogencarbonate; In ethanol; water; ethyl acetate; at 20 ℃;

upstream raw materials:

t-butoxycarbonylhydrazine

2,4,6-trifluorobenzonitrile

Downstream raw materials:

(2,6-difluoro-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzonitrile)