3β-(4'-propylphenyl)nortropane-2β-carboxylic acid methyl ester

Base Information

• Chemical Name: 3β-(4'-propylphenyl)nortropane-2β-carboxylic acid methyl ester
• CAS No.: 181796-55-4
• Molecular Formula: C₁₈H₂₅NO₂
• Molecular Weight: 287.402
• Mol file: 181796-55-4.mol

Synonyms:3β-(4'-propylphenyl)nortropane-2β-carboxylic acid methyl ester

Chemical Property of 3β-(4'-propylphenyl)nortropane-2β-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3β-(4'-propylphenyl)nortropane-2β-carboxylic acid methyl ester

There total 4 articles about 3β-(4'-propylphenyl)nortropane-2β-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

3β-(4'-propynylphenyl)nortropane-2β-carboxylic acid methyl ester (181796-54-3) → 3β-(4'-propylphenyl)nortropane-2β-carboxylic acid methyl ester (181796-55-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate;

DOI:10.1021/jm960409s

Reference yield:

(1R,2S,3S,5S)-3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester (135416-43-2,133647-95-7) → 3β-(4'-propylphenyl)nortropane-2β-carboxylic acid methyl ester (181796-55-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 96 percent / 1,2-dichloro-ethane / Heating

2: 97 percent / diisopropylamine, CuI, PdCl₂6H₅)3>2 / 258.6 Torr

3: 62 percent / Zn, glacial AcOH

4: 73 percent / H₂ / 10percent Pd/C / ethyl acetate

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; acetic acid; diisopropylamine; zinc; palladium on activated charcoal; In ethyl acetate; 1,2-dichloro-ethane;

DOI:10.1021/jm960409s

Reference yield:

(1R,2S,3S,5S)-3-(4-Iodo-phenyl)-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 2-methyl ester 8-(2,2,2-trichloro-ethyl) ester (156496-01-4) → 3β-(4'-propylphenyl)nortropane-2β-carboxylic acid methyl ester (181796-55-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / diisopropylamine, CuI, PdCl₂6H₅)3>2 / 258.6 Torr

2: 62 percent / Zn, glacial AcOH

3: 73 percent / H₂ / 10percent Pd/C / ethyl acetate

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; acetic acid; diisopropylamine; zinc; palladium on activated charcoal; In ethyl acetate;

DOI:10.1021/jm960409s

upstream raw materials:

3β-(4'-propynylphenyl)nortropane-2β-carboxylic acid methyl ester

(1R,2S,3S,5S)-3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester

(1R,2S,3S,5S)-3-(4-Iodo-phenyl)-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 2-methyl ester 8-(2,2,2-trichloro-ethyl) ester

(1R,2S,3S,5S)-3-(4-Prop-1-ynyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 2-methyl ester 8-(2,2,2-trichloro-ethyl) ester