3'-Acetyl-2'-deoxy-5-ethynyl-5'-(4,4'-dimethoxytrityl)uridine

Base Information

• Chemical Name: 3'-Acetyl-2'-deoxy-5-ethynyl-5'-(4,4'-dimethoxytrityl)uridine
• CAS No.: 117626-98-9
• Molecular Formula: C₃₄H₃₂N₂O₈
• Molecular Weight: 596.637
• Mol file: 117626-98-9.mol

Synonyms:3'-Acetyl-2'-deoxy-5-ethynyl-5'-(4,4'-dimethoxytrityl)uridine

Chemical Property of 3'-Acetyl-2'-deoxy-5-ethynyl-5'-(4,4'-dimethoxytrityl)uridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3'-Acetyl-2'-deoxy-5-ethynyl-5'-(4,4'-dimethoxytrityl)uridine

There total 1 articles about 3'-Acetyl-2'-deoxy-5-ethynyl-5'-(4,4'-dimethoxytrityl)uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic anhydride (108-24-7) + 5'-O-(4,4'-dimethoxytrityl)-5-(1-phenyl-1H-1,2,3-triazol-4-yl)-2'-deoxyuridine (117626-97-8) → 3'-Acetyl-2'-deoxy-5-ethynyl-5'-(4,4'-dimethoxytrityl)uridine (117626-98-9)

Guidance literature:

With pyridine; for 24h;

DOI:10.1021/jm00122a014

Reference yield:

3'-Acetyl-2'-deoxy-5-ethynyl-5'-(4,4'-dimethoxytrityl)uridine (117626-98-9) → 2'-deoxy-5-ethynyluridine (61135-33-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 0.16 g / 80percent aq. HOAc / 4.5 h

2: dicyclohexylcarbodiimide / pyridine / 72 h / Ambient temperature

3: 2 M NaOH / 2 h / Ambient temperature

With sodium hydroxide; acetic acid; dicyclohexyl-carbodiimide; In pyridine;

DOI:10.1021/jm00122a014

Reference yield:

3'-Acetyl-2'-deoxy-5-ethynyl-5'-(4,4'-dimethoxytrityl)uridine (117626-98-9) → 5-vinyl-2'-deoxyuridine (55520-67-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 0.16 g / 80percent aq. HOAc / 4.5 h

2: dicyclohexylcarbodiimide / pyridine / 72 h / Ambient temperature

3: 2 M NaOH / 2 h / Ambient temperature

4: H₂ / Lindlar catalyst (poisoned)

With sodium hydroxide; hydrogen; acetic acid; dicyclohexyl-carbodiimide; Lindlar's catalyst; In pyridine;

DOI:10.1021/jm00122a014

upstream raw materials:

acetic anhydride

5'-O-(4,4'-dimethoxytrityl)-5-(1-phenyl-1H-1,2,3-triazol-4-yl)-2'-deoxyuridine

Downstream raw materials:

3'-O-Acetyl-2'-deoxy-5-ethynyluridine

5-vinyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine

5'-O-(4,4'-dimethoxytrityl)-5-(1-phenyl-1H-1,2,3-triazol-4-yl)-2'-deoxyuridine

Sodium; {[(2R,3S,5R)-5-(2,4-dioxo-5-vinyl-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethoxy]-hydroxy-phosphoryl}-acetate