Technology Process of Cyclopropanecarboxaldehyde, 2-(1,3-hexadienyl)-, [1S-[1alpha,2alpha(1E,3Z)]]- (9CI)
There total 3 articles about Cyclopropanecarboxaldehyde, 2-(1,3-hexadienyl)-, [1S-[1alpha,2alpha(1E,3Z)]]- (9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) CuBr*SMe2, 2.) ZnBr2, 3.) Pd(PPh3)2 / 1.) Et2O, -40 deg C, 30 min, 2.) THF, -25 deg C, 20 min, 3.) Et2O, THF, pyrrolidine, 2 h
2: 99 percent / K2CO3 / methanol; H2O / 3 h / Ambient temperature
3: 1.) DMSO, oxalyl chloride, 2.) Et3N / 1.) CH2Cl2, -60 deg C, 25 min, 2.) -60 deg C to room temperature
With
oxalyl dichloride; copper(I) bromide dimethylsulfide complex; bis(triphenylphosphine)palladium(0); potassium carbonate; dimethyl sulfoxide; triethylamine; zinc dibromide;
In
methanol; water;
DOI:10.1016/S0040-4020(97)00886-7
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 99 percent / K2CO3 / methanol; H2O / 3 h / Ambient temperature
2: 1.) DMSO, oxalyl chloride, 2.) Et3N / 1.) CH2Cl2, -60 deg C, 25 min, 2.) -60 deg C to room temperature
With
oxalyl dichloride; potassium carbonate; dimethyl sulfoxide; triethylamine;
In
methanol; water;
DOI:10.1016/S0040-4020(97)00886-7
- Guidance literature:
-
With
oxalyl dichloride; dimethyl sulfoxide; triethylamine;
Yield given. Multistep reaction;
1.) CH2Cl2, -60 deg C, 25 min, 2.) -60 deg C to room temperature;
DOI:10.1016/S0040-4020(97)00886-7
