10-((3-chloro-4-methoxybenzyl)amino)-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile

Base Information

Chemical Name:10-((3-chloro-4-methoxybenzyl)amino)-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile
CAS No.:1448419-12-2
Molecular Formula:C₂₁H₁₉ClN₄O
Molecular Weight:378.861
Hs Code.:

Synonyms:10-((3-chloro-4-methoxybenzyl)amino)-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile

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Chemical Property of 10-((3-chloro-4-methoxybenzyl)amino)-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile

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Technology Process of 10-((3-chloro-4-methoxybenzyl)amino)-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile

There total 7 articles about 10-((3-chloro-4-methoxybenzyl)amino)-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1448419-28-0
tert-butyl 10-((3-chloro-4-methoxybenzyl)amino)-8-cyano-3,4-dihydrobenzo[b][1,6]naphthyridine-2-(1H)-carboxylate

: 1448419-12-2
10-((3-chloro-4-methoxybenzyl)amino)-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; diethyl ether; dichloromethane; at 20 ℃;

Reference yield:

: 99767-45-0
2-amino-5-cyanobenzoic acid

: 1448419-12-2
10-((3-chloro-4-methoxybenzyl)amino)-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: trichlorophosphate / 6 h / 60 °C

2: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 2 h / 0 °C / Reflux

3: dichloromethane / 1 h / 0 - 20 °C

4: triethylamine; sodium iodide / 1-methyl-pyrrolidin-2-one / 130 °C

5: hydrogenchloride / dichloromethane; 1,4-dioxane; diethyl ether / 20 °C

With hydrogenchloride; carbonochloridic acid 1-chloro-ethyl ester; triethylamine; sodium iodide; trichlorophosphate; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; diethyl ether; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 1448419-26-8
10-chloro-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile

: 1448419-12-2
10-((3-chloro-4-methoxybenzyl)amino)-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 1 h / 0 - 20 °C

2: triethylamine; sodium iodide / 1-methyl-pyrrolidin-2-one / 130 °C

3: hydrogenchloride / dichloromethane; 1,4-dioxane; diethyl ether / 20 °C

With hydrogenchloride; triethylamine; sodium iodide; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; diethyl ether; dichloromethane;