99767-45-0

Usage

Chemical Properties

Pale yellow solid

Upstream product

• 19619-22-8 2,4-dicyanoaniline 
• 159847-81-1 methyl 2-AMINO-5-CYANOBENZOATE 
• 52727-57-8 5-bromo-2-aminobenzoic acid methyl ester 
• 33348-34-4 4-amino-3-iodobenzonitrile 
• 5794-88-7 5-Bromo-2-aminobenzoic acid 
• 615-57-6 2,4-dibromo-aniline 

Downstream Products

• 668262-17-7 2-amino-5-cyano-benzoic acid benzyl ester 
• 668972-90-5 5-cyano-2-{[5-(4-fluorophenyl)oxazole-2-carbonyl]amino}benzoic acid tert-butyl ester 
• 1448419-06-4 10-[(3-chloro-4-methoxybenzyl)amino]-2-methyl-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile 
• 1448419-28-0 tert-butyl 10-((3-chloro-4-methoxybenzyl)amino)-8-cyano-3,4-dihydrobenzo[b][1,6]naphthyridine-2-(1H)-carboxylate 
• 1448419-12-2 10-((3-chloro-4-methoxybenzyl)amino)-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile 
• 1448419-13-3 2-acetyl-10-[(3-chloro-4-methoxybenzyl)amino]-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile 
• 1448419-25-7 2-benzyl-10-chloro-1,2,3,4-tetrahydrobenzo[b][1,6]-naphthyridine-8-carbonitrile 
• 668266-26-0 2-([1,1'-biphenyl]-4-ylcarboxamido)-5-cyanobenzoic acid 
• 159847-81-1 methyl 2-AMINO-5-CYANOBENZOATE 
• 1613465-80-7 2-(chloromethyl)-4-oxo-3-phenyl-3,4-dihydroquinazoline-6-carbonitrile 
• 1613465-34-1 (E)-5-cyano-2-((1,4-dimethylpiperazin-2-ylidene)amino)-N-phenylbenzamide 
• 1448419-07-5 10-[(3-chloro-4-methoxybenzyl)amino]-2-ethyl-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile 

Relevant academic research and scientific papers

Phosphodiesterase inhibitors and uses thereof

The invention provides for novel benzonaphthyridine derivatives and compositions comprising novel benzonaphthyridine derivatives. In some embodiments, the compounds are phosphodiesterase inhibitors. The invention further provides for methods for inhibitio

Identification of a Novel 1,2,3,4-Tetrahydrobenzo[b][1,6]naphthyridine Analogue as a Potent Phosphodiesterase 5 Inhibitor with Improved Aqueous Solubility for the Treatment of Alzheimer's Disease

Phosphodiesterase 5 (PDE5) hydrolyzes cyclic guanosine monophosphate (cGMP) leading to increased levels of the cAMP response element binding protein (CREB), a transcriptional factor involved with learning and memory processes. We previously reported poten

NOVEL PHOSPHODIESTERASE INHIBITORS AND USES THEREOF

The invention provides for novel benzonaphthyridine derivatives and compositions comprising novel benzonaphthyridine derivatives. In some embodiments, the compounds are phosphodiesterase inhibitors. The invention further provides for methods for inhibitio

6-SUBSTITUTED QUINAZOLINONE INHIBITORS

The present technology relates to compounds and compositions of Formulas I-III and methods using such compounds. The compounds and compositions described herein may be used in the treatment or prophylaxis of diseases associated with an alphavirus, for exa

Development of (E)-2-((1,4-Dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: Novel 2-Amidinophenylbenzamides as Potent Inhibitors of Venezuelan Equine Encephalitis Virus

Venezuelan equine encephalitis virus (VEEV) is an emerging pathogenic alphavirus that can cause significant disease in humans. Given the absence of therapeutic options available and the significance of VEEV as a weaponized agent, an optimization effort wa

NOVEL PHOSPHODIESTERASE INHIBITORS AND USES THEREOF

The invention provides for novel benzonaphthyridine derivatives and compositions comprising novel benzonaphthyridine derivatives. In some embodiments, the compounds are phosphodiesterase inhibitors. The invention further provides for methods for inhibitio

ANTIBACTERIAL BENZOIC ACID DERIVATIVES

The invention provides antimicrobial agents and methods of using the agents for sterilization, sanitation, antisepsis, disinfection, and treatment of infections in mammals.

ANTIBACTERIAL AGENTS

The present invention relates to antibacterial agents that are useful for sterilization, sanitation, antisepsis, and disinfection.

Regioselective Hydrolysis of Aromatic Dinitriles Using a Whole Cell Catalyst

A series of aromatic dinitriles have been examined as substrates for an immobilised whole cell Rhodococcus sp. that catalyses the hydrolysis of nitriles to amides and/or carboxylic acids.The fluorinated aromatic dinitriles 48 and 49 were regioselectively hydrolysed to the corresponding cyano amides 48a and 49a whereas the non-fluorinated analogues 41-44 were converted to cyano acids but with poorer regioselectivity.