(3R,4S)-3-cyclohexyl-4-(3,3,3-trifluoropropyl)-1-(2-tetrahydro-2H-pyran-2-yloxy)azetidin-2-one

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Chemical Name:(3R,4S)-3-cyclohexyl-4-(3,3,3-trifluoropropyl)-1-(2-tetrahydro-2H-pyran-2-yloxy)azetidin-2-one
CAS No.:382135-48-0
Molecular Formula:C₁₈H₂₈F₃NO₃
Molecular Weight:363.42
Hs Code.:

Synonyms:(3R,4S)-3-cyclohexyl-4-(3,3,3-trifluoropropyl)-1-(2-tetrahydro-2H-pyran-2-yloxy)azetidin-2-one

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Chemical Property of (3R,4S)-3-cyclohexyl-4-(3,3,3-trifluoropropyl)-1-(2-tetrahydro-2H-pyran-2-yloxy)azetidin-2-one

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Technology Process of (3R,4S)-3-cyclohexyl-4-(3,3,3-trifluoropropyl)-1-(2-tetrahydro-2H-pyran-2-yloxy)azetidin-2-one

There total 7 articles about (3R,4S)-3-cyclohexyl-4-(3,3,3-trifluoropropyl)-1-(2-tetrahydro-2H-pyran-2-yloxy)azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-6,6,6-Trifluoro-3-hydroxy-hexanoic acid methyl ester

: 382135-48-0
(3R,4S)-3-cyclohexyl-4-(3,3,3-trifluoropropyl)-1-(2-tetrahydro-2H-pyran-2-yloxy)azetidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 65 percent / LDA; DMPU / tetrahydrofuran / -78 - 0 °C

2: 55 percent / H₂ / Rh/Al₂O₃ / methanol / 3620.13 Torr

3: aq. LiOH / tetrahydrofuran; methanol / 24 h

4: DCC / ethyl acetate / 0 - 20 °C

5: pyridine / CH₂Cl₂ / 0 °C

6: K₂CO₃ / acetone / 12 h / Heating

With pyridine; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium hydroxide; hydrogen; potassium carbonate; dicyclohexyl-carbodiimide; lithium diisopropyl amide; Rh/Al₂O₃; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; acetone; 1: Frater-Seebach alkylation;
DOI:10.1021/jm0102654

Reference yield:

: 382135-39-9
methyl (3R)-6,6,6-trifluoro-3-hydroxy-2-phenylmethylhexanoate

: 382135-48-0
(3R,4S)-3-cyclohexyl-4-(3,3,3-trifluoropropyl)-1-(2-tetrahydro-2H-pyran-2-yloxy)azetidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 55 percent / H₂ / Rh/Al₂O₃ / methanol / 3620.13 Torr

2: aq. LiOH / tetrahydrofuran; methanol / 24 h

3: DCC / ethyl acetate / 0 - 20 °C

4: pyridine / CH₂Cl₂ / 0 °C

5: K₂CO₃ / acetone / 12 h / Heating

With pyridine; lithium hydroxide; hydrogen; potassium carbonate; dicyclohexyl-carbodiimide; Rh/Al₂O₃; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; acetone;
DOI:10.1021/jm0102654