(2S,3R,4R)-3,4-bis(tert-butyldimethylsilyloxy)-2-(pentyloxy)-1-tosylpiperidine

Base Information

Chemical Name:(2S,3R,4R)-3,4-bis(tert-butyldimethylsilyloxy)-2-(pentyloxy)-1-tosylpiperidine
CAS No.:1438279-88-9
Molecular Formula:C₂₉H₅₅NO₅SSi₂
Molecular Weight:585.996
Hs Code.:

Synonyms:(2S,3R,4R)-3,4-bis(tert-butyldimethylsilyloxy)-2-(pentyloxy)-1-tosylpiperidine

Suppliers and Price of (2S,3R,4R)-3,4-bis(tert-butyldimethylsilyloxy)-2-(pentyloxy)-1-tosylpiperidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R,4R)-3,4-bis(tert-butyldimethylsilyloxy)-2-(pentyloxy)-1-tosylpiperidine

Chemical Property:

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Technology Process of (2S,3R,4R)-3,4-bis(tert-butyldimethylsilyloxy)-2-(pentyloxy)-1-tosylpiperidine

There total 4 articles about (2S,3R,4R)-3,4-bis(tert-butyldimethylsilyloxy)-2-(pentyloxy)-1-tosylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 27607-77-8
trimethylsilyl trifluoromethanesulfonate

: 1438279-74-3
(2S,3R,4R)-2-(pentyloxy)-1-tosylpiperidine-3,4-diol

: 1438279-88-9
(2S,3R,4R)-3,4-bis(tert-butyldimethylsilyloxy)-2-(pentyloxy)-1-tosylpiperidine

Guidance literature:: With 1H-imidazole; dmap; In dichloromethane; N,N-dimethyl-formamide; Inert atmosphere;
DOI:10.1002/anie.201206967

Reference yield:

: 1438279-63-0
(S)-6-(pentyloxy)-1-tosyl-1,2,3,6-tetrahydropyridine

: 1438279-88-9
(2S,3R,4R)-3,4-bis(tert-butyldimethylsilyloxy)-2-(pentyloxy)-1-tosylpiperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 4-methyl-2-morpholinone; osmium(VIII) oxide / acetone; tetrahydrofuran; water / 0 - 20 °C / Inert atmosphere

2: 1H-imidazole; dmap / dichloromethane; N,N-dimethyl-formamide / Inert atmosphere

With 1H-imidazole; 4-methyl-2-morpholinone; dmap; osmium(VIII) oxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1002/anie.201206967

Reference yield:

: 1438280-00-2
(S)-N-(but-3-en-1-yl)-4-methyl-N-(1-(pentyloxy)allyl)benzenesulfonamide

: 1438279-88-9
(2S,3R,4R)-3,4-bis(tert-butyldimethylsilyloxy)-2-(pentyloxy)-1-tosylpiperidine

Guidance literature:: Multi-step reaction with 3 steps

1: Grubbs catalyst first generation / dichloromethane / 1 h / 20 °C / Inert atmosphere

2: 4-methyl-2-morpholinone; osmium(VIII) oxide / acetone; tetrahydrofuran; water / 0 - 20 °C / Inert atmosphere

3: 1H-imidazole; dmap / dichloromethane; N,N-dimethyl-formamide / Inert atmosphere

With 1H-imidazole; Grubbs catalyst first generation; 4-methyl-2-morpholinone; dmap; osmium(VIII) oxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1002/anie.201206967