(2R,3S,4S)-5-benzyloxy-4-methyl-2,3-epoxypentanoic acid

Base Information

Chemical Name:(2R,3S,4S)-5-benzyloxy-4-methyl-2,3-epoxypentanoic acid
CAS No.:106402-40-8
Molecular Formula:C₁₃H₁₆O₄
Molecular Weight:236.268
Hs Code.:

Synonyms:(2R,3S,4S)-5-benzyloxy-4-methyl-2,3-epoxypentanoic acid

Suppliers and Price of (2R,3S,4S)-5-benzyloxy-4-methyl-2,3-epoxypentanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3S,4S)-5-benzyloxy-4-methyl-2,3-epoxypentanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3S,4S)-5-benzyloxy-4-methyl-2,3-epoxypentanoic acid

There total 1 articles about (2R,3S,4S)-5-benzyloxy-4-methyl-2,3-epoxypentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 81520-04-9
(2S,3S,4S)-5-(benzyloxy)-2,3-epoxy-4-methyl-1-pentanol

: 106402-40-8
(2R,3S,4S)-5-benzyloxy-4-methyl-2,3-epoxypentanoic acid

Guidance literature:: With dipyridinium dichromate; In N,N-dimethyl-formamide; for 45h; Ambient temperature;
DOI:10.1016/S0040-4020(01)87959-X

Reference yield: 72.0%

: 106402-40-8
(2R,3S,4S)-5-benzyloxy-4-methyl-2,3-epoxypentanoic acid

: 104241-22-7
(2S,3S,4S)-2-amino-3-hydroxy-4-methyl-5-benzyloxypentanoic acid

Guidance literature:: With ammonium hydroxide; for 120h; Ambient temperature;
DOI:10.1016/S0040-4020(01)87959-X

Reference yield:

: 106402-40-8
(2R,3S,4S)-5-benzyloxy-4-methyl-2,3-epoxypentanoic acid

: tetrahydroechinocandin D

Guidance literature:: Multi-step reaction with 17 steps

1: 72 percent / 28percent aq. NH₃ / 120 h / Ambient temperature

2: NEt₃ / dioxane; H₂O / 4 h / Ambient temperature

3: diethyl ether

4: 45.3 percent / H₂ / 10percent Pd-C / methanol / 20 h / Ambient temperature

5: 0.5 NaOH / tetrahydrofuran / 16 h / 0 °C

6: diethyl ether

7: pyridine / 8 h / Ambient temperature

8: 62 percent / NaH / tetrahydrofuran / 1.5 h / 0 °C

9: CF₃COOH / CH₂Cl₂ / 0.5 h / Ambient temperature

10: diethylphosphoryl cyanide, NEt₃ / dimethylformamide / 15 h / 0 °C

12: 72 percent / diethylphosphoryl cyanide, NEt₃ / dimethylformamide / 1) 0 deg C, 1 h, 2) RT, 2 h

13: 100 percent / H₂ / 10percent Pd-C / methanol / 32 h / 760 Torr / Ambient temperature

14: 68 percent / diethylphosphoryl cyanide, NEt₃ / dimethylformamide / 38 h / 0 °C

15: 1) 0.5 N NaOH, 2) CF₃COOH / 1a) THF, 0 deg C, 19 h, 1b) RT, 8 h, 2) CH₂Cl₂, RT, 15 min

16: diphenylphosporyl azide, NEt₃ / dimethylformamide / 15 h / 0 °C

17: 100 percent / H₂ / 10percent Pd-C / methanol / 8 h / Ambient temperature

With pyridine; ammonium hydroxide; sodium hydroxide; diethylphosphoryl cyanide; diphenyl phosphoryl azide; hydrogen; sodium hydride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)87959-X