3-(tert-butyl-diphenyl-silanyloxy)-2-naphthalen-1-yl-propionic acid

Base Information

• Chemical Name: 3-(tert-butyl-diphenyl-silanyloxy)-2-naphthalen-1-yl-propionic acid
• CAS No.: 750594-75-3
• Molecular Formula: C₂₉H₃₀O₃Si
• Molecular Weight: 454.641
• Mol file: 750594-75-3.mol

Synonyms:3-(tert-butyl-diphenyl-silanyloxy)-2-naphthalen-1-yl-propionic acid

Chemical Property of 3-(tert-butyl-diphenyl-silanyloxy)-2-naphthalen-1-yl-propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(tert-butyl-diphenyl-silanyloxy)-2-naphthalen-1-yl-propionic acid

There total 7 articles about 3-(tert-butyl-diphenyl-silanyloxy)-2-naphthalen-1-yl-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(tert-butyl-diphenyl-silanyloxy)-2-naphthalen-1-yl-propan-1-ol → 3-(tert-butyl-diphenyl-silanyloxy)-2-naphthalen-1-yl-propionic acid (750594-75-3)

Guidance literature:

With jones reagent; In acetone; at 0 ℃; for 0.25h;

DOI:10.1021/ol048936q

Reference yield:

tert-butyl(diphenyl)(2-propynyloxy)silane (88159-06-2) → 3-(tert-butyl-diphenyl-silanyloxy)-2-naphthalen-1-yl-propionic acid (750594-75-3)

Guidance literature:

Multi-step reaction with 6 steps

1.1: biscyclopentadienylzirconium dichloride; lithium triethylborohydride / tetrahydrofuran / 2 h / 20 °C

1.2: 79 percent / I₂ / tetrahydrofuran / 10 h / 20 °C

2.1: t-BuLi; CeCl₃ / tetrahydrofuran; pentane / 1 h / -78 °C

2.2: 73 percent / tetrahydrofuran; pentane / 1 h / -78 °C

3.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 - 0 °C

3.2: tetrahydrofuran; hexane / 2 h / 0 - 20 °C

4.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

4.2: CuCN / tetrahydrofuran; hexane / 0.5 h / -78 °C

4.3: 1.50 g / tetrahydrofuran; hexane / 4 h / -78 - 20 °C

5.1: O₃; sudan III / CH₂Cl₂; methanol / -78 °C

5.2: NaBH₄ / CH₂Cl₂; methanol / 17.5 h / 0 - 20 °C

6.1: 314 mg / Jones reagent / acetone / 0.25 h / 0 °C

With n-butyllithium; jones reagent; cerium(III) chloride; zirconocene dichloride; oil scarlet; tert.-butyl lithium; lithium triethylborohydride; ozone; In tetrahydrofuran; methanol; hexane; dichloromethane; acetone; pentane;

DOI:10.1021/ol048936q

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → 3-(tert-butyl-diphenyl-silanyloxy)-2-naphthalen-1-yl-propionic acid (750594-75-3)

Guidance literature:

Multi-step reaction with 7 steps

1.1: biscyclopentadienylzirconium dichloride; lithium triethylborohydride / tetrahydrofuran / 2 h / 20 °C

1.2: 79 percent / I₂ / tetrahydrofuran / 10 h / 20 °C

2.1: t-BuLi; CeCl₃ / tetrahydrofuran; pentane / 1 h / -78 °C

2.2: 73 percent / tetrahydrofuran; pentane / 1 h / -78 °C

3.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 - 0 °C

3.2: tetrahydrofuran; hexane / 2 h / 0 - 20 °C

4.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

4.2: CuCN / tetrahydrofuran; hexane / 0.5 h / -78 °C

4.3: 1.50 g / tetrahydrofuran; hexane / 4 h / -78 - 20 °C

5.1: O₃; sudan III / CH₂Cl₂; methanol / -78 °C

5.2: NaBH₄ / CH₂Cl₂; methanol / 17.5 h / 0 - 20 °C

6.1: 314 mg / Jones reagent / acetone / 0.25 h / 0 °C

With n-butyllithium; jones reagent; cerium(III) chloride; zirconocene dichloride; oil scarlet; tert.-butyl lithium; lithium triethylborohydride; ozone; In tetrahydrofuran; methanol; hexane; dichloromethane; acetone; pentane;

DOI:10.1021/ol048936q

upstream raw materials:

tert-butyl(diphenyl)(2-propynyloxy)silane

tert-butylchlorodiphenylsilane

(E)-1-(tert-butyldiphenylsilyloxy)-3-iodoprop-2-ene

(1R,2S,5R)-1-[(E)-3-(tert-Butyl-diphenyl-silanyloxy)-propenyl]-2-isopropyl-5-methyl-cyclohexanol

Downstream raw materials:

[2-(tert-butyl-diphenyl-silanyloxy)-1-naphthalen-1-yl-ethyl]-carbamic acid methyl ester