5-{[6-(3-aminophenyl)pyrimidin-4-yl]amino}-2-methylphenyl isopropyl propylphosphonate

Base Information

Chemical Name:5-{[6-(3-aminophenyl)pyrimidin-4-yl]amino}-2-methylphenyl isopropyl propylphosphonate
CAS No.:1606168-24-4
Molecular Formula:C₂₃H₂₉N₄O₃P
Molecular Weight:440.482
Hs Code.:

Synonyms:5-{[6-(3-aminophenyl)pyrimidin-4-yl]amino}-2-methylphenyl isopropyl propylphosphonate

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Chemical Property of 5-{[6-(3-aminophenyl)pyrimidin-4-yl]amino}-2-methylphenyl isopropyl propylphosphonate

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Technology Process of 5-{[6-(3-aminophenyl)pyrimidin-4-yl]amino}-2-methylphenyl isopropyl propylphosphonate

There total 5 articles about 5-{[6-(3-aminophenyl)pyrimidin-4-yl]amino}-2-methylphenyl isopropyl propylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1606168-22-2
isopropyl 2-methyl-5-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl propylphosphonate

: 1606168-24-4
5-{[6-(3-aminophenyl)pyrimidin-4-yl]amino}-2-methylphenyl isopropyl propylphosphonate

Guidance literature:: With palladium 10% on activated carbon; ammonium formate; In methanol; dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm401742r

Reference yield:

: 915069-51-1
4-chloro-6-(3-nitrophenyl)-pyrimidine

: 1606168-24-4
5-{[6-(3-aminophenyl)pyrimidin-4-yl]amino}-2-methylphenyl isopropyl propylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / isopropyl alcohol; water / 1 h / Reflux

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

2.2: 20 °C

3.1: palladium 10% on activated carbon; ammonium formate / dichloromethane; methanol / 20 °C / Inert atmosphere

With hydrogenchloride; palladium 10% on activated carbon; potassium tert-butylate; ammonium formate; In tetrahydrofuran; methanol; dichloromethane; water; isopropyl alcohol;
DOI:10.1021/jm401742r

Reference yield:

: 2835-95-2
amino-4 hydroxy-2 toluene

: 1606168-24-4
5-{[6-(3-aminophenyl)pyrimidin-4-yl]amino}-2-methylphenyl isopropyl propylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / isopropyl alcohol; water / 1 h / Reflux

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

2.2: 20 °C

3.1: palladium 10% on activated carbon; ammonium formate / dichloromethane; methanol / 20 °C / Inert atmosphere

With hydrogenchloride; palladium 10% on activated carbon; potassium tert-butylate; ammonium formate; In tetrahydrofuran; methanol; dichloromethane; water; isopropyl alcohol;
DOI:10.1021/jm401742r