isopropyl 2-methyl-5-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl propylphosphonate

Base Information

Chemical Name:isopropyl 2-methyl-5-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl propylphosphonate
CAS No.:1606168-22-2
Molecular Formula:C₂₃H₂₇N₄O₅P
Molecular Weight:470.465
Hs Code.:

Synonyms:isopropyl 2-methyl-5-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl propylphosphonate

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Chemical Property of isopropyl 2-methyl-5-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl propylphosphonate

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Technology Process of isopropyl 2-methyl-5-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl propylphosphonate

There total 4 articles about isopropyl 2-methyl-5-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl propylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 13213-45-1
(propan-2-yloxy)(propyl)phosphinoyl chloride

: 1606168-14-2
2-methyl-5-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenol

: 1606168-22-2
isopropyl 2-methyl-5-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl propylphosphonate

Guidance literature:: 2-methyl-5-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenol; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 0.5h;

(propan-2-yloxy)(propyl)phosphinoyl chloride; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm401742r

Reference yield:

: 915069-51-1
4-chloro-6-(3-nitrophenyl)-pyrimidine

: 1606168-22-2
isopropyl 2-methyl-5-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl propylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / isopropyl alcohol; water / 1 h / Reflux

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

2.2: 20 °C

With hydrogenchloride; potassium tert-butylate; In tetrahydrofuran; water; isopropyl alcohol;
DOI:10.1021/jm401742r

Reference yield:

: 2835-95-2
amino-4 hydroxy-2 toluene

: 1606168-22-2
isopropyl 2-methyl-5-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl propylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / isopropyl alcohol; water / 1 h / Reflux

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

2.2: 20 °C

With hydrogenchloride; potassium tert-butylate; In tetrahydrofuran; water; isopropyl alcohol;
DOI:10.1021/jm401742r