(2S,3R,5S)-5-isopropenyl-2-methyl-3-trimethylsilylcyclohexanone

Base Information

• Chemical Name: (2S,3R,5S)-5-isopropenyl-2-methyl-3-trimethylsilylcyclohexanone
• CAS No.: 871228-10-3
• Molecular Formula: C₁₃H₂₄OSi
• Molecular Weight: 224.418
• Mol file: 871228-10-3.mol

Synonyms:(2S,3R,5S)-5-isopropenyl-2-methyl-3-trimethylsilylcyclohexanone

Chemical Property of (2S,3R,5S)-5-isopropenyl-2-methyl-3-trimethylsilylcyclohexanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (2S,3R,5S)-5-isopropenyl-2-methyl-3-trimethylsilylcyclohexanone

There total 1 articles about (2S,3R,5S)-5-isopropenyl-2-methyl-3-trimethylsilylcyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1,1,1,2,2,2-hexamethyldisilane (1450-14-2) + (R)-Carvone (6485-40-1,2244-16-8) → (2S,3R,5S)-5-isopropenyl-2-methyl-3-trimethylsilylcyclohexanone (871228-10-3)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; methyllithium; In tetrahydrofuran; diethyl ether; at -78 ℃; for 1h;

DOI:10.1016/j.tet.2005.09.025

Reference yield: 52.0%

(2S,3R,5S)-5-isopropenyl-2-methyl-3-trimethylsilylcyclohexanone (871228-10-3) + methyl vinyl ketone (78-94-4,25038-87-3) → (2R,3R,5S)-5-isopropenyl-2-methyl-2-(3-oxobutyl)-3-(trimethylsilyl)cyclohexanone (871228-11-4)

Guidance literature:

With Ph₃CSbCl₃; at 0 ℃; for 24h;

DOI:10.1016/j.tet.2005.09.025

Reference yield:

(2S,3R,5S)-5-isopropenyl-2-methyl-3-trimethylsilylcyclohexanone (871228-10-3) + methyl vinyl ketone (78-94-4,25038-87-3) → (2R,3R,5S)-5-isopropenyl-2-methyl-2-(3-oxobutyl)-3-(trimethylsilyl)cyclohexanone (871228-11-4) + 3-((1R,4S,6R)-4-Isopropenyl-1-methyl-2-oxo-6-trimethylsilanyl-cyclohexylmethyl)-heptane-2,6-dione

Guidance literature:

With Ph₃CSbCl₃; at 0 ℃;

DOI:10.1016/j.tet.2005.09.025

upstream raw materials:

1,1,1,2,2,2-hexamethyldisilane

(R)-Carvone

Downstream raw materials:

(2R,3R,5S)-5-isopropenyl-2-methyl-2-(3-oxobutyl)-3-(trimethylsilyl)cyclohexanone