(2R,4R,5S,6R)-2-benzoyloxy-4-(tert-butyldiphenylsilanyloxymethyl)-5,6-dibenzyloxy-cyclohexanone

Base Information

Chemical Name:(2R,4R,5S,6R)-2-benzoyloxy-4-(tert-butyldiphenylsilanyloxymethyl)-5,6-dibenzyloxy-cyclohexanone
CAS No.:867258-72-8
Molecular Formula:C₄₄H₄₆O₆Si
Molecular Weight:698.931
Hs Code.:

Synonyms:(2R,4R,5S,6R)-2-benzoyloxy-4-(tert-butyldiphenylsilanyloxymethyl)-5,6-dibenzyloxy-cyclohexanone

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Chemical Property of (2R,4R,5S,6R)-2-benzoyloxy-4-(tert-butyldiphenylsilanyloxymethyl)-5,6-dibenzyloxy-cyclohexanone

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Technology Process of (2R,4R,5S,6R)-2-benzoyloxy-4-(tert-butyldiphenylsilanyloxymethyl)-5,6-dibenzyloxy-cyclohexanone

There total 6 articles about (2R,4R,5S,6R)-2-benzoyloxy-4-(tert-butyldiphenylsilanyloxymethyl)-5,6-dibenzyloxy-cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.4%

: 867258-68-2
1-O-benzoyl-3,4-di-O-benzyl-6-O-(tert-butyldiphenyl)silyl-5a-carba-β-D-idopyranose

: 867258-72-8
(2R,4R,5S,6R)-2-benzoyloxy-4-(tert-butyldiphenylsilanyloxymethyl)-5,6-dibenzyloxy-cyclohexanone

Guidance literature:: With 4 A molecular sieve; pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 7h;
DOI:10.1016/j.tetasy.2005.07.010

Reference yield:

: 867258-70-6
3,4-di-O-benzyl-6-O-(tert-butyldiphenyl)silyl-5a-carba-β-D-idopyranose

: 867258-72-8
(2R,4R,5S,6R)-2-benzoyloxy-4-(tert-butyldiphenylsilanyloxymethyl)-5,6-dibenzyloxy-cyclohexanone

Guidance literature:: Multi-step reaction with 2 steps

1: 91.9 percent / Et₃N; Me₂SnCl₂ / tetrahydrofuran / 6 h / 20 °C

2: 97.4 percent / molecular sieves 4 Angstoem; pyridinium chlorochromate / CH₂Cl₂ / 7 h / 20 °C

With 4 A molecular sieve; dimethyltin dichloride; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetasy.2005.07.010

Reference yield:

: 867258-77-3
6-O-(tert-butyldiphenyl)silyl-1,2-di-O-(methoxymethyl)-5a-carba-β-D-idopyranose

: 867258-72-8
(2R,4R,5S,6R)-2-benzoyloxy-4-(tert-butyldiphenylsilanyloxymethyl)-5,6-dibenzyloxy-cyclohexanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / tetrahydrofuran / 0 - 20 °C

1.2: 78 percent / Bu₄NI / tetrahydrofuran / 24 h / 20 °C

2.1: 69 percent / molecular sieves 4 Angstroem; TMSBr / CH₂Cl₂ / 2 h / -20 °C

3.1: 91.9 percent / Et₃N; Me₂SnCl₂ / tetrahydrofuran / 6 h / 20 °C

4.1: 97.4 percent / molecular sieves 4 Angstoem; pyridinium chlorochromate / CH₂Cl₂ / 7 h / 20 °C

With trimethylsilyl bromide; 4 A molecular sieve; dimethyltin dichloride; sodium hydride; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetasy.2005.07.010