(11beta,16alpha)-9-Fluoro-11,17-dihydroxy-21-iodo-16-methylpregna-1,4-diene-3,20-dione

Base Information

Chemical Name:(11beta,16alpha)-9-Fluoro-11,17-dihydroxy-21-iodo-16-methylpregna-1,4-diene-3,20-dione
CAS No.:2029-18-7
Molecular Formula:C22H28 F I O4
Molecular Weight:502.36
Hs Code.:
DSSTox Substance ID:DTXSID001135597
Mol file:2029-18-7.mol

Synonyms:DTXSID001135597;(11beta,16alpha)-9-Fluoro-11,17-dihydroxy-21-iodo-16-methylpregna-1,4-diene-3,20-dione

Suppliers and Price of (11beta,16alpha)-9-Fluoro-11,17-dihydroxy-21-iodo-16-methylpregna-1,4-diene-3,20-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Dexamethasone21-Iodide
100mg
$ 150.00

Total 6 raw suppliers

Chemical Property of (11beta,16alpha)-9-Fluoro-11,17-dihydroxy-21-iodo-16-methylpregna-1,4-diene-3,20-dione

Chemical Property:

PSA：74.60000
LogP:3.33840
XLogP3:2.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:502.10164
Heavy Atom Count:28
Complexity:808

Purity/Quality:

99% ^*data from raw suppliers

Dexamethasone21-Iodide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CI)O)C)O)F)C
Isomeric SMILES:C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CI)O)C)O)F)C
Uses Dexamethasone 21-Iodide is a derivative of Dexamethasone (D298800), a glucocorticoid used as an anti-inflammatory agent.

Technology Process of (11beta,16alpha)-9-Fluoro-11,17-dihydroxy-21-iodo-16-methylpregna-1,4-diene-3,20-dione

There total 2 articles about (11beta,16alpha)-9-Fluoro-11,17-dihydroxy-21-iodo-16-methylpregna-1,4-diene-3,20-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.3%

: 2265-22-7
Dexamethasone 21-mesylate

: 2029-18-7
9-fluoro-11β,17-dihydroxy-21-iodo-16α-methylpregn-4-ene-3,20-dione

Guidance literature:: With sodium iodide; In acetone; for 0.666667h; Heating;

Reference yield:

: 50-02-2
dexamethasone

: 2029-18-7
9-fluoro-11β,17-dihydroxy-21-iodo-16α-methylpregn-4-ene-3,20-dione

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 1.5 h / 0 °C

2: NaI / acetone / 2 h / Heating

With pyridine; sodium iodide; In acetone;
DOI:10.1016/0223-5234(91)90137-C