o-Ethoxycarbonylbenzenesulfonamide

Base Information

• Chemical Name: o-Ethoxycarbonylbenzenesulfonamide
• CAS No.: 2026-37-1
• Molecular Formula: C27H42 N4 O7
• Molecular Weight: 230.26088
• Mol file: 2026-37-1.mol

Synonyms:D-Valine,N-[N-[N-[N-[(phenylmethoxy)carbonyl]-L-alanyl]-D-valyl]-L-valyl]-, methylester; Valine, N-[N-[N-(N-carboxy-L-alanyl)-D-valyl]-L-valyl]-, N-benzyl methylester (7CI)

Chemical Property of o-Ethoxycarbonylbenzenesulfonamide

Chemical Property:

• PSA: 151.93000
• LogP: 3.46030

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of o-Ethoxycarbonylbenzenesulfonamide

There total 7 articles about o-Ethoxycarbonylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

D-Valine methyl ester hydrochloride (7146-15-8) → Z-Ala-D-Val-Val-D-Val-OMe (2026-37-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / HOBt; NEt₃; EDC / CH₂Cl₂ / 12 h / 0 - 20 °C

2: LiOH / tetrahydrofuran; H₂O / 0 °C

3: 2.44 g / HOBt; DIEA; HBTU / CH₂Cl₂; dimethylformamide / 1 h / 0 °C

With lithium hydroxide; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(02)00179-5

Reference yield:

(S)-N-(benzyloxycarbonyl)valine (1149-26-4) → Z-Ala-D-Val-Val-D-Val-OMe (2026-37-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / HOBt; NEt₃; EDC / CH₂Cl₂ / 18 h / 20 °C

2: H₂ / 15 percent Pd/C / 750.06 Torr

3: 2.44 g / HOBt; DIEA; HBTU / CH₂Cl₂; dimethylformamide / 1 h / 0 °C

With hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(02)00179-5

Reference yield:

Z-L-Val-D-Val-OMe (72635-90-6) → Z-Ala-D-Val-Val-D-Val-OMe (2026-37-1)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 15 percent Pd/C / 750.06 Torr

2: 2.44 g / HOBt; DIEA; HBTU / CH₂Cl₂; dimethylformamide / 1 h / 0 °C

With hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(02)00179-5

upstream raw materials:

L-Val-D-Val-OMe

Z-L-Ala-D-Val-OH

N-Cbz-Ala

(S)-N-(benzyloxycarbonyl)valine

Downstream raw materials:

(R)-2-{(S)-2-[(R)-2-((S)-2-Benzyloxycarbonylamino-propionylamino)-3-methyl-butyrylamino]-3-methyl-butyrylamino}-3-methyl-butyric acid