ethyl 3-acetyl-2-methyl-6-phenylisonicotinate

Base Information

Chemical Name:ethyl 3-acetyl-2-methyl-6-phenylisonicotinate
CAS No.:855636-08-7
Molecular Formula:C₁₇H₁₇NO₃
Molecular Weight:283.327
Hs Code.:

Synonyms:ethyl 3-acetyl-2-methyl-6-phenylisonicotinate

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Chemical Property of ethyl 3-acetyl-2-methyl-6-phenylisonicotinate

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Technology Process of ethyl 3-acetyl-2-methyl-6-phenylisonicotinate

There total 6 articles about ethyl 3-acetyl-2-methyl-6-phenylisonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: C₁₄H₁₅NO₄

: 123-54-6,81235-32-7
acetylacetone

: 855636-08-7
ethyl 3-acetyl-2-methyl-6-phenylisonicotinate

Guidance literature:: With copper(l) iodide; In tetrahydrofuran; at 120 ℃; for 12h; Inert atmosphere; Schlenk technique; Sealed tube;
DOI:10.1021/acs.joc.9b03238

Reference yield: 80.0%

: 1118-66-7
4-amino-3-penten-2-one

: 6296-54-4
ethyl 2,4-dioxo-4-phenylbutyrate

: 855636-08-7
ethyl 3-acetyl-2-methyl-6-phenylisonicotinate

Guidance literature:: With acetic acid; at 30 ℃; for 72h; Inert atmosphere;
DOI:10.1007/s10593-011-0659-6

Reference yield:

: 20913-05-7,859-65-4
(Benzoylmethylene)triphenylphosphorane

: 855636-08-7
ethyl 3-acetyl-2-methyl-6-phenylisonicotinate

Guidance literature:: Multi-step reaction with 4 steps

1: chloroform / 12 h / 20 °C / Inert atmosphere

2: hydroxylamine hydrochloride; pyridine / methanol / 20 °C / Inert atmosphere

3: 3 h / 100 °C / Inert atmosphere

4: copper(l) iodide / tetrahydrofuran / 12 h / 120 °C / Inert atmosphere; Schlenk technique; Sealed tube

With pyridine; copper(l) iodide; hydroxylamine hydrochloride; In tetrahydrofuran; methanol; chloroform;
DOI:10.1021/acs.joc.9b03238