6296-54-4

Usage

Uses

Used in Food and Beverage Industry:
ETHYL 2,4-DIOXO-4-PHENYLBUTANOATE is used as a flavoring agent to impart a pleasant and fruity taste to food and beverages, enhancing the overall sensory experience for consumers.
Used in Perfume Production:
In the perfume industry, ETHYL 2,4-DIOXO-4-PHENYLBUTANOATE is utilized as a component to create complex and appealing fragrances, capitalizing on its sweet and fruity scent.
Used in Cosmetic Products:
ETHYL 2,4-DIOXO-4-PHENYLBUTANOATE is also employed in the formulation of cosmetic products, where it adds a desirable aroma, contributing to the product's overall appeal and consumer satisfaction.
It is crucial to handle ETHYL 2,4-DIOXO-4-PHENYLBUTANOATE with care due to its potential harmful effects if ingested or inhaled in large amounts, emphasizing the need for proper safety measures during its use in various applications.

InChI:InChI=1/C12H12O4/c1-2-16-12(15)11(14)8-10(13)9-6-4-3-5-7-9/h3-7H,2,8H2,1H3

Upstream product

• 64-17-5 ethanol 
• 141-52-6 sodium ethanolate 
• 98-86-2 acetophenone 
• 95-92-1 oxalic acid diethyl ester 
• 100-52-7 benzaldehyde 
• 98-85-1 1-Phenylethanol 
• 5817-92-5 2,4-dioxo-4-phenylbutanoic acid 
• 99-90-1 para-bromoacetophenone 
• 7647-01-0 hydrogenchloride 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Downstream Products

• 97341-51-0 Ethyl 2,4-dihydroxy-7-phenylpyrido[2,3-d]pyrimidine-5-carboxylate 
• 871890-52-7 3,5-dibenzoyl-2,6-dioxo-heptanedioic acid diethyl ester 
• 855636-08-7 ethyl 3-acetyl-2-methyl-6-phenylisonicotinate 
• 873989-76-5 4-benzoyl-5-hexyl-dihydro-furan-2,3-dione 
• 112271-76-8 2,4-dioxo-1,7-diphenyl-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidine-5-carboxylic acid ethyl ester 
• 116636-35-2 1-(4-ethoxy-phenyl)-2,4-dioxo-7-phenyl-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidine-5-carboxylic acid ethyl ester 
• 71-43-2 benzene 
• 2783-70-2 2-phenacylbenzothiazole N-methyl enaminone 
• 5817-92-5 2,4-dioxo-4-phenylbutanoic acid 
• 5932-30-9 ethyl 5-phenylpyrazole-3-carboxylate 
• 14441-90-8 5-phenyl-3-isoxazolecarboxylic acid 
• 86387-66-8 4-benzoyl-5-methyltetrahydrofuran-2,3-dione 
• 7063-99-2 ethyl 5-phenylisoxazole-3-carboxylate 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 

Relevant academic research and scientific papers

Synthesis of pyrazine-2,3-dicarbonitriles via the one-pot three-component reaction of 4-benzoyl-5-phenylamino-2,3-dihydrothiophene-2,3-dione, diaminomaleonitrile, and functionalized alcohols in acetonitrile

An efficient one-pot three-component reaction of 4-benzoyl-5-phenylamino-2,3-dihydrothiophene-2,3-dione, diaminomaleonitrile, and alcohols with hetero-atom substituents or several hydroxyl groups in acetonitrile solvent under reflux led to the formation o

A simple and versatile protocol for the preparation of functionalized heterocycles utilizing 4-benzoyl-5-phenylamino-2,3-dihydrothiophene-2,3-dione

The reaction of ethyl benzoylpyruvate with phenyl isothiocyanate in alkaline medium yields 4-benzoyl-5-phenylamino-2,3-dihydrothiophene-2,3-dione (1). Reaction of the intermediate 1 with primary aromatic amines such as aniline derivatives, benzidine and s

Reactions of 4-benzoyl-5-phenylamino-2,3-dihydrothiophene-2,3-dione and diaminomaleonitrile in the presence of alcohols as reactant and solvent

The one-pot synthesis of a novel class of 5-(2-alkoxy-2-phenyl-1-N-phenylthiocarbamoylethenyl)-6-oxo-1,6-dihydropyrazine-2,3-dicarbonitriles (2a–o) is achieved in moderate to good yields by the sequential reaction between 4-benzoyl-5-phenylamino-2,3-dihyd

Synthesis of Organic Ligands via Reactions of 4-Benzoyl-5-phenylamino-2,3-dihydrothiophene-2,3-dione with N -Nucleophiles

The reaction of 4-benzoyl-5-phenylamino-2,3-dihydrothiophene-2,3-dione (1) with aminoheteroaryls, lamotrigine, 1,3-diaminoheteroaryls, dapsone, NH2R (hydroxylamine, DL-1-phenylethylamine, and metformin), and 4,4′-bipyridine in THF/H2O (1: 1) at room tempe

Small-molecule vasopressin-2 receptor antagonist identified by a G-protein coupled receptor "pathway" screen

G-protein-coupled receptors (GPCRs) such as the vasopressin-2 receptor (V2R) are an important class of drug targets. We developed an efficient screen for GPCR-induced cAMP elevation using as read-out cAMP activation of cystic fibrosis transmemb

Novel Substituted Purine Isosteres: Synthesis, Structure-Activity Relationships and Cytotoxic Activity Evaluation

A number of pyrrolo[2,3-c]pyridines, pyrrolo[3,2-d]pyrimidines and pyrazolo[4,3-d]pyrimidines were designed and synthesized as antiproliferative agents. The target compounds possessed selected substituents in analogous positions on the central scaffold th

Design, synthesis, and biological activity evaluation of 2-(benzo[b]thiophen-2-yl)-4-phenyl-4,5-dihydrooxazole derivatives as broad-spectrum antifungal agents

To discover antifungal compounds with broad-spectrum and stable metabolism, a series of 2-(benzo[b]thiophen-2-yl)-4-phenyl-4,5-dihydrooxazole derivatives was designed and synthesized. Compounds A30-A34 exhibited excellent broad-spectrum antifungal activity against Candida albicans with MIC values in the range of 0.03–0.5 μg/mL, and against Cryptococcus neoformans and Aspergillus fumigatus with MIC values in the range of 0.25–2 μg/mL. In addition, compounds A31 and A33 showed high metabolic stability in human liver microsomes in vitro, with the half-life of 80.5 min and 69.4 min, respectively. Moreover, compounds A31 and A33 showed weak or almost no inhibitory effect on the CYP3A4 and CYP2D6. The pharmacokinetic evaluation in SD rats showed that compound A31 had suitable pharmacokinetic properties and was worthy of further study.

Synthesis and Biological Screening of Novel 5-(5-Aryl-1-phenyl-1H-pyrazol-3-yl)-3-aryl-1,2,4-oxadiazole Derivatives

A new series of 5-(5-aryl-1-phenyl-1H-pyrazol-3-yl)-3-aryl-1,2,4-oxadiazole (6a-o) have been synthesized by a cyclocondensation reaction of ethyl 5-(4-chlorophenyl)-1-phenyl-1H-pyrazole-3-carboxylate (3a-c) with aryl imidoxime (5a-e). The newly synthesize

ISPH INHIBITORS, AND METHODS OF MAKING AND USING SAME

In one aspect, the invention provides novel compounds useful for treating bacterial infections, such as but not limited to Gram-negative bacterial infections. In another aspect, the invention provides novel compounds useful for activating γδ T cell respon

Lewis acid-promoted synthesis of highly substituted pyrrole-fused benzoxazinones and quinoxalinones

A synthesis of a series of novel fused tricyclic heterocyclic compounds has been achieved in one-pot reaction set up starting from (E)-3-(2-oxo-2-phenylethylidene)indolin-2-one and 1,4-benzoxazinone/quinoxalinone derivatives promoted by tin(IV) chloride.